Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | neuropeptide receptor | 0.0143 | 0.1207 | 0.1207 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.015 | 0.1318 | 0.0126 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1207 | 0.1207 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0688 | 1 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.015 | 0.1318 | 0.1318 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | neuropeptide receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | biogenic amine receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | histamine h1 receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | P2X receptor subunit | 0.015 | 0.1318 | 0.1318 |
Schistosoma mansoni | P2X receptor subunit | 0.015 | 0.1318 | 0.1318 |
Schistosoma mansoni | opsin-like receptor | 0.0143 | 0.1207 | 0.1207 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0688 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1207 | 0.1207 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0688 | 1 | 1 |
Schistosoma mansoni | myosin xvIII | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0143 | 0.1207 | 0.1207 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0688 | 1 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0143 | 0.1207 | 0.1207 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.015 | 0.1318 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0688 | 1 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | amine GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0143 | 0.1207 | 0.1207 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0688 | 1 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | adenoreceptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0688 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0143 | 0.1207 | 0.1207 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.015 | 0.1318 | 0.0126 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0143 | 0.1207 | 0.1207 |
Echinococcus granulosus | lysosomal protective protein | 0.0688 | 1 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | biogenic amine receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | neuropeptide receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1207 | 0.1207 |
Echinococcus multilocularis | lysosomal protective protein | 0.0688 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0688 | 1 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0688 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.062 | 0.8903 | 0.8753 |
Schistosoma mansoni | opsin-like receptor | 0.0143 | 0.1207 | 0.1207 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.062 | 0.8903 | 0.8753 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0688 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0143 | 0.1207 | 0.1207 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.015 | 0.1318 | 0.0126 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0688 | 1 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.015 | 0.1318 | 0.0126 |
Schistosoma mansoni | amine GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | amine GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0143 | 0.1207 | 0.1207 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.015 | 0.1318 | 0.0126 |
Schistosoma mansoni | biogenic amine receptor | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | amine GPCR | 0.0143 | 0.1207 | 0.1207 |
Schistosoma mansoni | P2X receptor subunit | 0.015 | 0.1318 | 0.1318 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0688 | 1 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0143 | 0.1207 | 0.1207 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10000 nM | Inhibitory activity against thrombin | ChEMBL. | 9544200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.