Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0146 | 0.3128 | 0.888 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0267 | 0.7191 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0158 | 0.3522 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.3522 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0185 | 0.4423 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.3522 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.035 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0116 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.035 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0146 | 0.3128 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.3128 | 0.888 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.035 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0166 | 0.3793 | 0.3643 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 50 % | Reduction of serum triglycerides in CF1 male mice on day 16 following 20 mg/kg/day i.p. administration. | ChEMBL. | 6737419 |
Control (functional) | = 75 % | Reduction of serum cholesterol in CF1 male mice on day 16 following 20 mg/kg/day i.p. administration. | ChEMBL. | 6737419 |
Control (functional) | = 76 % | Reduction of serum cholesterol in CF1 male mice on day 9 following 20 mg/kg/day i.p. administration. | ChEMBL. | 6737419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.