Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.0392 | 0.527 | 0.527 |
Echinococcus granulosus | tumor protein p63 | 0.0392 | 0.527 | 0.527 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0706 | 1 | 0.5 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0637 | 0.895 | 0.895 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.007 | 0.0422 | 0.0422 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0706 | 1 | 1 |
Echinococcus multilocularis | lysosomal protective protein | 0.0706 | 1 | 1 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0637 | 0.895 | 0.895 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0706 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0706 | 1 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0706 | 1 | 0.5 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0706 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0706 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0706 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0706 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0706 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0706 | 1 | 0.5 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0706 | 1 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.0235 | 0.0235 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0706 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 30.2 uM | Cytotoxicity against human KB cells assessed as growth inhibition after 48 hrs by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.