Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.002 | 0.0259 | 0.4227 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0064 | 0.313 | 0.313 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0612 | 1 |
Leishmania major | ubiquitin activating enzyme, putative | 0.002 | 0.0259 | 0.4227 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.0064 | 0.313 | 1 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0064 | 0.313 | 0.313 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0612 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0612 | 1 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.002 | 0.0259 | 0.4227 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0064 | 0.313 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0046 | 0.1971 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0612 | 1 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.002 | 0.0259 | 0.4227 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0612 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0612 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0612 | 0.1956 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0031 | 0.0098 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0064 | 0.313 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0612 | 0.1956 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0612 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0064 | 0.313 | 0.313 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0064 | 0.313 | 1 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.002 | 0.0259 | 0.4227 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0612 | 0.1956 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.002 | 0.0259 | 0.4227 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 47.8 % | Antimigratory activity against human MDA-MB-231 cells assessed cell migration level at 30 uM by wound healing assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.