Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 M | Concentration required to inhibit HIV-1 replication by 50% in acutelyinfected H9 lymphocytes; NA means not active | ChEMBL. | 15149703 |
IC50 (functional) | = 339 uM | Concentration required to inhibit uninfected H9 cell growth by 50% | ChEMBL. | 15149703 |
IC50 (functional) | = 339 uM | Concentration required to inhibit uninfected H9 cell growth by 50% | ChEMBL. | 15149703 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.