Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0052 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0052 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0052 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0052 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0052 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0052 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0052 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0052 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0052 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0052 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0052 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0046 | 0.7743 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0052 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0032 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0052 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0032 | 0.2407 | 0.2407 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0052 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0052 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0052 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0046 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0026 | 0 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0052 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0052 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0052 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0026 | 0.0151 | 0.0151 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0052 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | > 600 mg kg-1 | Tested for antiinflammatory activity in the mouse active Arthus (MAA) test by per oral administration | ChEMBL. | 6461764 |
ID50 (functional) | > 600 mg kg-1 | Tested for antiinflammatory activity in the mouse active Arthus (MAA) test by per oral administration | ChEMBL. | 6461764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.