TDR Targets

Basic information

Technical information

TDR Targets ID: 185840
Name: N-(4-phenylphenyl)-7-sulfanylheptanamide
MW: 313.457 | Formula: C19H23NOS
H donors: 1 H acceptors: 1 LogP: 4.56 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: SCCCCCCC(=O)Nc1ccc(cc1)c1ccccc1
InChi: 1S/C19H23NOS/c21-19(10-6-1-2-7-15-22)20-18-13-11-17(12-14-18)16-8-4-3-5-9-16/h3-5,8-9,11-14,22H,1-2,6-7,10,15H2,(H,20,21)
InChiKey: QTXIBRBGYJCFEU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-phenylphenyl)-7-sulfanyl-heptanamide
7-mercapto-N-(4-phenylphenyl)heptanamide
7-mercapto-N-(4-phenylphenyl)enanthamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	histone deacetylase 9	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium berghei	histone deacetylase 2, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma congolense	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania mexicana	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus multilocularis	histone deacetylase 6	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium falciparum	histone deacetylase 2	Get druggable targets OG5_126654	All targets in OG5_126654
Candida albicans	strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania mexicana	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Neospora caninum	hypothetical protein	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma japonicum	Histone deacetylase 4, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania major	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium yoelii	Histone deacetylase family, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus granulosus	histone deacetylase 6	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium falciparum	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126654	All targets in OG5_126654
Theileria parva	hypothetical protein	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium knowlesi	histone deacetylase 2, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma cruzi	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus granulosus	histone deacetylase 7	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus granulosus	histone deacetylase 6	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium berghei	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma brucei	histone deacetylase 3	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium knowlesi	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Loa Loa (eye worm)	histone deacetylase	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania donovani	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus multilocularis	histone deacetylase	Get druggable targets OG5_126654	All targets in OG5_126654
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus granulosus	histone deacetylase 6	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma brucei	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Brugia malayi	Histone deacetylase family protein	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma japonicum	Histone deacetylase 6, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania braziliensis	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma congolense	histone deacetylase 4	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium vivax	histone deacetylase 2, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma japonicum	Histone deacetylase 10, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma mansoni	histone deacetylase hda2	Get druggable targets OG5_126654	All targets in OG5_126654
Plasmodium vivax	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma cruzi	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma mansoni	histone deacetylase 4 5	Get druggable targets OG5_126654	All targets in OG5_126654
Brugia malayi	Histone deacetylase family protein	Get druggable targets OG5_126654	All targets in OG5_126654
Theileria parva	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania infantum	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma japonicum	Histone deacetylase 10, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Babesia bovis	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Loa Loa (eye worm)	histone deacetylase 7A	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania infantum	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma cruzi	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma congolense	histone deacetylase 4	Get druggable targets OG5_126654	All targets in OG5_126654
Candida albicans	strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma mansoni	histone deacetylase 4 5	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus multilocularis	histone deacetylase 6	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma japonicum	IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing	Get druggable targets OG5_126654	All targets in OG5_126654
Theileria parva	hypothetical protein	Get druggable targets OG5_126654	All targets in OG5_126654
Toxoplasma gondii	histone deacetylase HDAC1	Get druggable targets OG5_126654	All targets in OG5_126654
Cryptosporidium parvum	histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus multilocularis	histone deacetylase 7	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus multilocularis	histone deacetylase 6	Get druggable targets OG5_126654	All targets in OG5_126654
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania braziliensis	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania major	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma japonicum	Histone deacetylase 4, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Echinococcus granulosus	histone deacetylase	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma brucei gambiense	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126654	All targets in OG5_126654
Schistosoma japonicum	Histone deacetylase 6, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Leishmania donovani	histone deacetylase, putative	Get druggable targets OG5_126654	All targets in OG5_126654
Trypanosoma brucei	histone deacetylase 4	Get druggable targets OG5_126654	All targets in OG5_126654

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Giardia lamblia	Kinase, NEK	0.0839	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase Blk	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Entamoeba histolytica	protein kinase, putative	0.1251	0.3294	0.3294
Schistosoma mansoni	tyrosine kinase	0.209	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1251	0.3294	0.3294
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1251	0.3294	0.3294
Schistosoma mansoni	suppressor of cytokine signaling	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Brugia malayi	SH2 domain containing protein	0.1251	0.3294	0.3294
Plasmodium falciparum	protein kinase, putative	0.0839	0	0.5
Onchocerca volvulus		0.209	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0839	0	0.5
Onchocerca volvulus		0.209	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Onchocerca volvulus		0.209	1	1
Toxoplasma gondii	protein kinase	0.0839	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1251	0.3294	0.3294
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0839	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.209	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.209	1	1
Brugia malayi	SH2 domain containing protein	0.1251	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Giardia lamblia	Protein 21.1	0.0839	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0839	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.1251	0.3294	0.3294
Trichomonas vaginalis	conserved hypothetical protein	0.0839	0	0.5
Giardia lamblia	Kinase	0.0839	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0839	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0839	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0839	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.1251	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1251	0.3294	0.3294
Echinococcus granulosus	growth factor receptor bound protein 2	0.1251	0.3294	0.3294
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1251	0.3294	0.3294
Schistosoma mansoni	tyrosine kinase	0.209	1	1
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Echinococcus multilocularis	N chimaerin	0.1251	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus granulosus	N chimaerin	0.1251	0.3294	0.3294
Echinococcus granulosus	NCK adaptor protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	conserved hypothetical protein	0.0839	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Brugia malayi	Variant SH3 domain containing protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	SH2 domain-containing protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	SH2 domain-containing protein	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase Lyn	0.209	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1251	0.3294	0.3294
Brugia malayi	SH2 domain containing protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0839	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.209	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1251	0.3294	0.3294
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1251	0.3294	0.3294
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0839	0	0.5
Echinococcus granulosus	hypothetical protein	0.1251	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0839	0	0.5
Echinococcus granulosus	tensin	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1251	0.3294	0.3294
Brugia malayi	RhoGAP domain containing protein	0.1251	0.3294	0.3294
Trypanosoma brucei	protein kinase, putative	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Schistosoma mansoni	tyrosine kinase	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase Fyn	0.209	1	1
Schistosoma mansoni	tyrosine kinase	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.1251	0.3294	0.3294
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0839	0	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.209	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1251	0.3294	0.3294
Echinococcus multilocularis	SH2 motif	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase Src42A	0.209	1	1
Plasmodium falciparum	protein kinase, putative	0.0839	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.209	1	1
Brugia malayi	SH2 domain containing protein	0.1251	0.3294	0.3294
Trypanosoma cruzi	protein kinase, putative	0.0839	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.1251	0.3294	0.3294
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1251	0.3294	0.3294
Trichomonas vaginalis	conserved hypothetical protein	0.0839	0	0.5
Echinococcus multilocularis	tensin	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.209	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase Srms	0.209	1	1
Loa Loa (eye worm)	hypothetical protein	0.209	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Schistosoma mansoni	hypothetical protein	0.1251	0.3294	0.3294
Toxoplasma gondii	STE kinase	0.0839	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Brugia malayi	SH2 domain containing protein	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Brugia malayi	hypothetical protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Onchocerca volvulus		0.209	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	SRC-1	0.209	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0839	0	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1251	0.3294	0.3294
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1251	0.3294	0.3294
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1251	0.3294	0.3294
Brugia malayi	SRC-1	0.209	1	1
Schistosoma mansoni	vav2	0.1251	0.3294	0.3294
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.209	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.209	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1251	0.3294	0.3294
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0839	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Schistosoma mansoni	tensin	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase shark	0.209	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1251	0.3294	0.3294
Schistosoma mansoni	hypothetical protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus granulosus	SH2 motif	0.1251	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.209	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.209	1	1
Schistosoma mansoni	tensin-related	0.1251	0.3294	0.3294
Schistosoma mansoni	shc transforming protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1251	0.3294	0.3294
Leishmania major	protein kinase, putative	0.0839	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.1251	0.3294	0.3294
Echinococcus granulosus	c src tyrosine kinase	0.209	1	1
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase Fyn	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1251	0.3294	0.3294
Echinococcus granulosus	signal transduction protein lnk realted	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Leishmania major	protein kinase, putative	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.209	1	1
Onchocerca volvulus		0.1251	0.3294	0.3294
Schistosoma mansoni	growth factor receptor-bound protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	SH2 domain-containing protein	0.1251	0.3294	0.3294
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.209	1	1
Leishmania major	hypothetical protein, conserved	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.209	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0839	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0839	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.209	1	1
Onchocerca volvulus		0.1251	0.3294	0.3294
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0839	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0839	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.209	1	1
Giardia lamblia	Kinase, NEK	0.0839	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.209	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0839	0	0.5
Plasmodium vivax	protein kinase, putative	0.0839	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0839	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Schistosoma mansoni	tyrosine kinase	0.209	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1251	0.3294	0.3294
Trypanosoma cruzi	protein kinase, putative	0.0839	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	protein kinase atn1, putative	0.0839	0	0.5
Onchocerca volvulus		0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Brugia malayi	SH2 domain containing protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Schistosoma mansoni	tensin-related	0.1251	0.3294	0.3294
Brugia malayi	Tyrosine-protein kinase abl-1	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Schistosoma mansoni	tyrosine kinase	0.209	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.1251	0.3294	0.3294
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1251	0.3294	0.3294
Brugia malayi	SH2 domain containing protein	0.1251	0.3294	0.3294
Brugia malayi	Protein kinase domain containing protein	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Onchocerca volvulus		0.1251	0.3294	0.3294
Echinococcus multilocularis	tyrosine kinase	0.209	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase Fyn	0.209	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.209	1	1
Echinococcus multilocularis	NCK adaptor protein	0.1251	0.3294	0.3294
Brugia malayi	SH2 domain containing protein	0.1251	0.3294	0.3294
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1251	0.3294	0.3294
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1251	0.3294	0.3294
Schistosoma mansoni	SH2A	0.1251	0.3294	0.3294
Schistosoma mansoni	tensin	0.1251	0.3294	0.3294
Trichomonas vaginalis	CAMK family protein kinase	0.0839	0	0.5
Brugia malayi	SH2 domain containing protein	0.209	1	1
Echinococcus granulosus	tyrosine kinase	0.209	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.209	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1251	0.3294	0.3294
Echinococcus granulosus	tyrosine protein kinase ABL1	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.1251	0.3294	0.3294
Toxoplasma gondii	protein kinase domain-containing protein	0.0839	0	0.5
Echinococcus multilocularis	SH2 motif	0.1251	0.3294	0.3294
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1251	0.3294	0.3294
Echinococcus multilocularis	c src tyrosine kinase	0.209	1	1
Echinococcus granulosus	tyrosine kinase	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1251	0.3294	0.3294
Schistosoma mansoni	nck2/grb4	0.1251	0.3294	0.3294
Schistosoma mansoni	tensin	0.1251	0.3294	0.3294
Brugia malayi	Tensin	0.1251	0.3294	0.3294
Brugia malayi	hypothetical protein	0.209	1	1
Onchocerca volvulus		0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus multilocularis	SH2 motif	0.1251	0.3294	0.3294
Echinococcus multilocularis	tyrosine protein kinase Blk	0.209	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Echinococcus multilocularis		0.1251	0.3294	0.3294
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0839	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0839	0	0.5
Echinococcus granulosus	SH2 motif	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Onchocerca volvulus		0.1251	0.3294	0.3294
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0839	0	0.5
Echinococcus granulosus	expressed conserved protein	0.1251	0.3294	0.3294
Loa Loa (eye worm)	TK/FER protein kinase	0.209	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.209	1	1
Schistosoma mansoni	GTPase activating protein	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Onchocerca volvulus		0.209	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1251	0.3294	0.3294
Echinococcus multilocularis	signal transduction protein lnk realted	0.1251	0.3294	0.3294
Loa Loa (eye worm)	STAT protein	0.1251	0.3294	0.3294
Onchocerca volvulus		0.1251	0.3294	0.3294
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1251	0.3294	0.3294
Echinococcus multilocularis	tensin	0.1251	0.3294	0.3294
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0839	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.209	1	1
Brugia malayi	protein-tyrosine kinase	0.209	1	1
Schistosoma mansoni	adapter molecule crk	0.1251	0.3294	0.3294
Trichomonas vaginalis	TK family protein kinase	0.0839	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0839	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1251	0.3294	0.3294

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.1 uM	In vitro inhibitory activity against human histone deacetylase (HDAC) using HeLa nuclear extract	ChEMBL.	15149697
IC50 (binding)	= 1.1 uM	Inhibitory concentration against human histone deacetylase	ChEMBL.	15715470
IC50 (binding)	= 1.1 uM	In vitro inhibitory activity against human histone deacetylase (HDAC) using HeLa nuclear extract	ChEMBL.	15149697
IC50 (binding)	= 1.1 uM	Inhibitory concentration against human histone deacetylase	ChEMBL.	15715470

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11220728

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 185840