Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | SEA domain containing protein | 0.0025 | 0.236 | 0.1418 |
Onchocerca volvulus | 0.0044 | 0.6806 | 0.6412 | |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | 0.0044 | 0.6806 | 0.6412 | |
Brugia malayi | Cation transporter family protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | ACC-1 protein | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0044 | 0.6806 | 0.6412 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | nAChR subunit | 0.0044 | 0.6806 | 0.6806 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | LGC-31 protein | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0023 | 0.1918 | 0.1918 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.1918 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0023 | 0.1918 | 0.1918 |
Onchocerca volvulus | 0.0023 | 0.1918 | 0.0922 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | nAChR subunit | 0.0044 | 0.6806 | 0.6806 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | 0.0044 | 0.6806 | 0.6412 | |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | 0.0044 | 0.6806 | 0.6412 | |
Onchocerca volvulus | 0.0023 | 0.1918 | 0.0922 | |
Loa Loa (eye worm) | GABA receptor subunit | 0.0023 | 0.1918 | 0.0922 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | Muscle positioning protein 4 | 0.0025 | 0.236 | 0.1418 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0044 | 0.6806 | 0.6412 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0057 | 1 | 0.5 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0023 | 0.1918 | 0.0922 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Echinococcus granulosus | nAChR subunit | 0.0023 | 0.1918 | 0.0922 |
Schistosoma mansoni | nAChR subunit | 0.0044 | 0.6806 | 0.6806 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0044 | 0.6806 | 0.6806 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Echinococcus granulosus | nAChR subunit | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0023 | 0.1918 | 0.0922 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | 0.0025 | 0.236 | 0.1418 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0044 | 0.6806 | 0.6806 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.002 | 0.112 | 0.112 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0044 | 0.6806 | 0.6412 |
Leishmania major | hypothetical protein, conserved | 0.0057 | 1 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | Cation transporter family protein | 0.0044 | 0.6806 | 0.6412 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Echinococcus multilocularis | nAChR subunit | 0.0044 | 0.6806 | 0.6412 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0044 | 0.6806 | 0.6412 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | Putative nachr subunit | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.1097 | 0.1097 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0044 | 0.6806 | 0.6412 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.236 | 0.1418 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0044 | 0.6806 | 0.6412 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.002 | 0.1097 | 0.1097 |
Onchocerca volvulus | 0.0044 | 0.6806 | 0.6412 | |
Onchocerca volvulus | 0.0044 | 0.6806 | 0.6412 | |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0044 | 0.6806 | 0.6412 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | nAChR subunit | 0.002 | 0.1097 | 0.1097 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 1 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0044 | 0.6806 | 0.6412 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.236 | 0.1418 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0044 | 0.6806 | 0.6412 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0044 | 0.6806 | 0.6412 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0044 | 0.6806 | 0.6806 |
Onchocerca volvulus | 0.0025 | 0.236 | 0.1418 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0023 | 0.1918 | 0.0922 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.236 | 0.236 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0044 | 0.6806 | 0.6806 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0023 | 0.1918 | 0.1918 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0044 | 0.6806 | 0.6806 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | Kringle domain containing protein | 0.0057 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0044 | 0.6806 | 0.6806 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0044 | 0.6806 | 0.6806 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0025 | 0.236 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Schistosoma mansoni | nAChR subunit | 0.0044 | 0.6806 | 0.6806 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | 0.0025 | 0.236 | 0.1418 | |
Schistosoma mansoni | acetylcholine receptor-related | 0.002 | 0.1097 | 0.1097 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0044 | 0.6806 | 0.6412 |
Echinococcus multilocularis | nAChR subunit | 0.0023 | 0.1918 | 0.0922 |
Schistosoma mansoni | nAChR subunit | 0.0044 | 0.6806 | 0.6806 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.002 | 0.1097 | 0.1097 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | 0.0025 | 0.236 | 0.1418 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | nAChR subunit | 0.0044 | 0.6806 | 0.6806 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0023 | 0.1918 | 0.0922 |
Toxoplasma gondii | kringle domain-containing protein | 0.0057 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0057 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | 0.0057 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1918 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 1 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0044 | 0.6806 | 0.6412 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0044 | 0.6806 | 0.6412 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.002 | 0.1097 | 0.1097 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0044 | 0.6806 | 0.6412 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0044 | 0.6806 | 0.6412 |
Onchocerca volvulus | 0.0025 | 0.236 | 0.1418 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.