Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuropeptide receptor A26 | 0.0475 | 0.5617 | 1 |
Schistosoma mansoni | glutaminase | 0.0281 | 0.3239 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0281 | 0.3239 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0475 | 0.5617 | 0.5617 |
Echinococcus multilocularis | geminin | 0.0174 | 0.1932 | 0.1932 |
Brugia malayi | glutaminase DH11.1 | 0.0281 | 0.3239 | 1 |
Echinococcus granulosus | geminin | 0.0174 | 0.1932 | 0.344 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.023 | 0.071 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1342 | 0.4143 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.0387 | 0.4537 | 1 | |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0111 | 0.1159 | 0.3577 |
Loa Loa (eye worm) | glutaminase 2 | 0.0281 | 0.3239 | 1 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.011 | 0.1152 | 0.3557 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0475 | 0.5617 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | transcription factor eb | 0.0111 | 0.1159 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1152 | 0.3557 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0428 | 0.1322 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0475 | 0.5617 | 0.5617 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0428 | 0.1322 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor eb | 0.0111 | 0.1159 | 0.1159 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.023 | 0.071 |
Trichomonas vaginalis | glutaminase, putative | 0.0281 | 0.3239 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.023 | 0.071 |
Brugia malayi | hypothetical protein | 0.0126 | 0.1342 | 0.4143 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0428 | 0.1322 |
Mycobacterium ulcerans | glutaminase | 0.0281 | 0.3239 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1342 | 0.4143 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1932 | 0.5966 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0428 | 0.1322 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1932 | 0.5966 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Metabolism (functional) | = 10.4 uM min-1mg-1 | NADH oxidation is used as a measure of the compound metabolism since 1 mol of NADH is oxidized for each mole of compound that is reduced | ChEMBL. | 11563930 |
Metabolism (functional) | = 10.4 uM min-1mg-1 | NADH oxidation is used as a measure of the compound metabolism since 1 mol of NADH is oxidized for each mole of compound that is reduced | ChEMBL. | 11563930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.