Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transient receptor potential channel | 0.0286 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0286 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0286 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0286 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0286 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0286 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0286 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0286 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 32 uM kg-1 | In vivo ability to inhibit bronchospasm induced by intravenous doses of histamine on the artificially respired, anesthetized guinea pig | ChEMBL. | 1527785 |
ED50 (functional) | = 32 uM kg-1 | In vivo ability to inhibit bronchospasm induced by intravenous doses of histamine on the artificially respired, anesthetized guinea pig | ChEMBL. | 1527785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.