Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.004 | 0.004 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.004 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0324 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0353 | 0.0353 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0393 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.004 | 0.1028 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.004 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0855 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0324 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0855 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0393 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.004 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.0353 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.004 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.004 | 0.1028 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.004 | 0.1145 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.0353 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0295 | 0.0295 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 165 uM | Compound dose required to reduce the viability of mock-infected cells by 50% | ChEMBL. | 7650679 |
CC50 (functional) | = 165 uM | Compound dose required to reduce the viability of mock-infected cells by 50% | ChEMBL. | 7650679 |
EC50 (functional) | > 165 uM | Dose required to achieve 50% protection of MT-4 cells from HIV-1 induced cytopathogenicity | ChEMBL. | 7650679 |
EC50 (functional) | > 165 uM | Dose required to achieve 50% protection of MT-4 cells from HIV-1 induced cytopathogenicity | ChEMBL. | 7650679 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.