Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Indolethylamine N-methyltransferase | Starlite/ChEMBL | References |
Homo sapiens | indolethylamine N-methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | Get druggable targets OG5_132055 | All targets in OG5_132055 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132055 | All targets in OG5_132055 |
Brugia malayi | NNMT/PNMT/TEMT family protein | Get druggable targets OG5_132055 | All targets in OG5_132055 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132055 | All targets in OG5_132055 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | Indolethylamine N-methyltransferase | 263 aa | 214 aa | 22.0 % |
Onchocerca volvulus | Putative Werner syndrome ATP-dependent helicase homolog 1 | Indolethylamine N-methyltransferase | 263 aa | 233 aa | 24.5 % |
Giardia lamblia | Hypothetical protein | indolethylamine N-methyltransferase | 262 aa | 258 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1492 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1492 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1492 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.5 uM | Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C]adenosylmethionine | ChEMBL. | 423205 |
IC50 (binding) | = 6 uM | Inhibition of human lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C]adenosylmethionine | ChEMBL. | 423205 |
Inhibition (binding) | = 84 % | Inhibition of human lung INMT-mediated methylation of tryptamine at 1.76 x 10'4 M by liquid scintillation counting | ChEMBL. | 423205 |
Inhibition (binding) | = 85 % | Inhibition of human lung INMT-mediated methylation of serotonin at 1.76 x 10'4 M by liquid scintillation counting | ChEMBL. | 423205 |
Inhibition (binding) | = 88 % | Inhibition of human lung INMT-mediated methylation of N-methylserotonin at 1.76 x 10'4 M by liquid scintillation counting | ChEMBL. | 423205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.