Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nitric-oxide synthase, brain | No references | |
Bos taurus | Nitric-oxide synthase, endothelial | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | sulfite reductase | 0.0053 | 0.2407 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0086 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0086 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0086 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0086 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0086 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0086 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0076 | 0.7743 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0053 | 0.2407 | 0.2407 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0086 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0086 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0086 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0086 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0043 | 0.0151 | 0.0151 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0086 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0076 | 0.7743 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0086 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0086 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0086 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0086 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0086 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0086 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0086 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0086 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0086 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 66 nM | Inhibition Assay | BINDINGDB. | No reference |
Ki (binding) | = 7240 nM | Inhibition Assay | BINDINGDB. | No reference |
Ki (binding) | = 28400 nM | Inhibition Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.