Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium channel, subfamily K, member 3 | Starlite/ChEMBL | References |
Homo sapiens | potassium channel, subfamily K, member 9 | Starlite/ChEMBL | References |
Rattus norvegicus | Potassium channel subfamily K member 3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 35 | Potassium channel subfamily K member 3 | 411 aa | 410 aa | 25.1 % |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 28 | potassium channel, subfamily K, member 3 | 394 aa | 450 aa | 24.2 % |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 12 | potassium channel, subfamily K, member 9 | 374 aa | 309 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.0692 | 1 | 0.5 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0692 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0692 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0692 | 1 | 1 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.0692 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0.028 uM | PubChem BioAssay. SAR Analysis for the identification of inhibitors of the two-pore domain potassium channel TASK1 (KCNK3). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | = 0.029 uM | Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | ChEMBL. | 25017033 |
IC50 (functional) | 0.06 uM | PubChem BioAssay. SAR analysis for the identification of selective inhibitors of the two-pore domain potassium channel TASK1(KCNK3):Automated Electrophysiology. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | = 0.06 uM | Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay | ChEMBL. | 25017033 |
IC50 (binding) | = 0.75 uM | Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay | ChEMBL. | 25017033 |
IC50 (functional) | 0.99 uM | PubChem BioAssay. SAR analysis for the identification of selective inhibitors of the two-pore domain potassium channel TASK1(KCNK3) -selectivity assay against TASK3(KCNK9): Automated Electrophysiology. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | = 0.99 uM | Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay | ChEMBL. | 25017033 |
IC50 (functional) | 1.05 uM | PubChem BioAssay. SAR analysis for compounds that inhibit the two-pore domain potassium channel TASK1- Selectivity assay against TASK3 (KCNK9): FluxOR Assay CRC. (Class of assay: confirmatory) | ChEMBL. | No reference |
Inhibition (binding) | = 93.4 % | Inhibition of TASK-1 (unknown origin) expressed in CHO cells at 3 uM by thallium flux assay | ChEMBL. | 25017033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.