Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Homo sapiens | galactosylceramidase | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 1 | 1 | |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0022 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 1 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0022 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 1 | 1 | |
Echinococcus granulosus | Mastin | 0.0022 | 1 | 1 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 1 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0022 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0022 | 1 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 1 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0022 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 1 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 1 | 1 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0022 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 1 | 1 | |
Echinococcus multilocularis | Mastin | 0.0022 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0022 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0022 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0022 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 1 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0022 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.3333 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.007 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.4591 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.