Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | laminin | 0.0284 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0391 | 0.0313 | 0.5 |
Onchocerca volvulus | 0.1044 | 0.221 | 1 | |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0391 | 0.0313 | 0.0313 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0391 | 0.0313 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1044 | 0.221 | 0.221 |
Toxoplasma gondii | PAN domain-containing protein | 0.1637 | 0.3933 | 1 |
Brugia malayi | Trypsin family protein | 0.1044 | 0.221 | 0.221 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.3725 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1044 | 0.221 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | laminin | 0.0284 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3725 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3725 | 1 | 1 |
Onchocerca volvulus | 0.0888 | 0.1757 | 0.7949 | |
Echinococcus multilocularis | Tolloid protein 1 | 0.0284 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1044 | 0.221 | 0.221 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0391 | 0.0313 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1044 | 0.221 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.1637 | 0.3933 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 0.0313 | 0.0313 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 3 % | Inhibition of type-3 17 beta-hydroxysteroid dehydrogenase expressed in HEK-293 cells at 0.3 uM 37 degree C pH 7.4 | ChEMBL. | 16078844 |
Inhibition (binding) | = 94 % | Inhibition of type-3 17 beta-hydroxysteroid dehydrogenase expressed in HEK-293 cells at 3 uM 37 degree C pH 7.4 | ChEMBL. | 16078844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.