Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 3'partial|nardilysin | 0.0262 | 1 | 1 |
Schistosoma mansoni | family M16 unassigned peptidase (M16 family) | 0.0103 | 0.1529 | 0.1529 |
Echinococcus granulosus | nardilysin | 0.0262 | 1 | 1 |
Echinococcus multilocularis | nardilysin | 0.0262 | 1 | 1 |
Leishmania major | phosphoglycan beta 1,3 galactosyltransferase 5 | 0.0262 | 1 | 0.5 |
Echinococcus multilocularis | insulin degrading enzyme | 0.0262 | 1 | 1 |
Echinococcus granulosus | insulin degrading enzyme | 0.0262 | 1 | 1 |
Toxoplasma gondii | toxolysin TLN4 | 0.0117 | 0.2249 | 0.0849 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0117 | 0.2243 | 1 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0262 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0191 | 0.6219 | 0.3133 |
Chlamydia trachomatis | insulinase family protease III | 0.0262 | 1 | 0.5 |
Echinococcus multilocularis | nardilysin | 0.0262 | 1 | 1 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0262 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0127 | 0.2804 | 0.2804 |
Toxoplasma gondii | sporozoite developmental protein | 0.0262 | 1 | 1 |
Toxoplasma gondii | rhoptry metalloprotease toxolysin TLN1 | 0.0262 | 1 | 1 |
Toxoplasma gondii | peptidase M16 inactive domain-containing protein | 0.0159 | 0.4495 | 0.3501 |
Onchocerca volvulus | Matrilysin homolog | 0.0117 | 0.2243 | 1 |
Trypanosoma cruzi | peptidase, putative | 0.0262 | 1 | 0.5 |
Schistosoma mansoni | insulysin (M16 family) | 0.0146 | 0.381 | 0.381 |
Trypanosoma cruzi | peptidase, putative | 0.0262 | 1 | 0.5 |
Trypanosoma brucei | peptidase, putative | 0.0262 | 1 | 0.5 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0262 | 0.9966 | 0.9966 |
Loa Loa (eye worm) | matrixin family protein | 0.0127 | 0.2804 | 0.0723 |
Loa Loa (eye worm) | insulin-degrading enzyme | 0.0262 | 1 | 1 |
Toxoplasma gondii | insulysin, putative | 0.0249 | 0.9281 | 0.9151 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0191 | 0.6219 | 0.5144 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0262 | 0.9966 | 0.9966 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 2.59 | Calculated partition coefficient (clogP) | ChEMBL. | 15177439 |
IC50 (binding) | = 1.5 nM | Inhibitory activity against matrix metalloproteinase-13 (MMP-13) | ChEMBL. | 15177439 |
IC50 (binding) | = 1.5 nM | Inhibitory activity against matrix metalloproteinase-13 (MMP-13) | ChEMBL. | 15177439 |
IC50 (binding) | = 750 nM | Inhibitory activity against human matrix metalloproteinase-1 (MMP-1) | ChEMBL. | 15177439 |
IC50 (binding) | = 750 nM | Inhibitory activity against human matrix metalloproteinase-1 (MMP-1) | ChEMBL. | 15177439 |
Inhibition (functional) | = 51 % | Inhibition of MMP-13 induced experimental arthritis in hamster knee by 30 mg/kg p.o. | ChEMBL. | 15177439 |
Inhibition (functional) | = 51 % | Inhibition of MMP-13 induced experimental arthritis in hamster knee by 30 mg/kg p.o. | ChEMBL. | 15177439 |
Ratio (functional) | = 45 | Extraction ratio in rat liver microsomes. | ChEMBL. | 15177439 |
Ratio (binding) | = 500 | Ratio of IC50 of MMP-1 to that of MMP-13 was determined | ChEMBL. | 15177439 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.