Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | high affinity cgmp specific 3' 5' cyclic | 0.0137 | 0.4069 | 0.4069 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0097 | 0.1149 | 0.5 |
Plasmodium falciparum | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0137 | 0.4069 | 0.5 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.0082 | 0 | 0.5 |
Loa Loa (eye worm) | PDE1B protein | 0.0216 | 1 | 1 |
Onchocerca volvulus | 0.0097 | 0.1149 | 0.5 | |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0082 | 0 | 0.5 |
Echinococcus granulosus | high affinity cgmp specific 3' 5' cyclic | 0.0137 | 0.4069 | 0.4069 |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0082 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0097 | 0.1149 | 0.1149 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0216 | 1 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0137 | 0.4069 | 1 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0082 | 0 | 0.5 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.0082 | 0 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0216 | 1 | 1 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0137 | 0.4069 | 0.3299 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0216 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0097 | 0.1149 | 0.1149 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 39.9 uM | Effective dose required for relaxation of the 30 mM KCl-induced contraction of rat aortic rings | ChEMBL. | 12852765 |
IC50 (functional) | < 1 uM | Concentration required to inhibit insulin release in rat | ChEMBL. | 12852765 |
ND (functional) | 0 | Inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 0.1 microM concentration; Not determined | ChEMBL. | 12852765 |
RIS (functional) | = 2.1 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 50 microM concentration | ChEMBL. | 12852765 |
RIS (functional) | = 10.7 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 10 microM concentration | ChEMBL. | 12852765 |
RIS (functional) | = 29.2 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 1 microM concentration | ChEMBL. | 12852765 |
Selectivity (functional) | > 40 | Estimated selectivity ratio of ED50 and IC50 in rat was calculated | ChEMBL. | 12852765 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.