TDR Targets

Basic information

Technical information

TDR Targets ID: 187084
Name: 7,8-dichloro-1-(trifluoromethyl)-5H-[1,2,4]tr iazolo[4,3-a]quinoxalin-4-one
MW: 323.058 | Formula: C10H3Cl2F3N4O
H donors: 1 H acceptors: 4 LogP: 3.68 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc2nc(O)c3n(c2cc1Cl)c(nn3)C(F)(F)F
InChi: 1S/C10H3Cl2F3N4O/c11-3-1-5-6(2-4(3)12)19-7(8(20)16-5)17-18-9(19)10(13,14)15/h1-2H,(H,16,20)
InChiKey: OKCLRFHZPOCCAL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7,8-dichloro-1-(trifluoromethyl)-5H-[1,2,4]triazolo[3,4-c]quinoxalin-4-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Glutamate (NMDA) receptor subunit zeta 1	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate receptor ionotropic, AMPA	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Glutamate receptor ionotropic, AMPA	907 aa	959 aa	30.9 %
Onchocerca volvulus	Putative 39S ribosomal protein L45, mitochondrial	Glutamate receptor ionotropic, AMPA	907 aa	799 aa	37.7 %
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	Glutamate (NMDA) receptor subunit zeta 1	938 aa	822 aa	23.2 %
Onchocerca volvulus		Glutamate receptor ionotropic, AMPA	907 aa	796 aa	40.5 %
Echinococcus granulosus	glutamate receptor 2	Glutamate receptor ionotropic, AMPA	907 aa	875 aa	30.4 %
Drosophila melanogaster	Glutamate receptor IA	Glutamate (NMDA) receptor subunit zeta 1	938 aa	979 aa	23.7 %
Schistosoma mansoni	glutamate receptor kainate	Glutamate receptor ionotropic, AMPA	907 aa	753 aa	33.2 %
Drosophila melanogaster	NMDA receptor 2	Glutamate (NMDA) receptor subunit zeta 1	938 aa	878 aa	27.4 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	779 aa	33.4 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	809 aa	33.6 %
Echinococcus multilocularis	glutamate receptor 2	Glutamate receptor ionotropic, AMPA	907 aa	868 aa	30.4 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	779 aa	33.4 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	809 aa	34.1 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	888 aa	34.0 %
Drosophila melanogaster	Glutamate receptor IIB	Glutamate receptor ionotropic, AMPA	907 aa	863 aa	27.8 %
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Glutamate receptor ionotropic, AMPA	907 aa	948 aa	30.6 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	886 aa	34.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	fmrfamide receptor	0.0107	0.3639	0.3639
Echinococcus granulosus	fmrfamide receptor	0.0107	0.3639	0.1574
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0107	0.3639	0.1574
Brugia malayi	larval opioid receptor	0.0107	0.3639	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	Dopamine receptor protein 2	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0107	0.3639	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0107	0.3639	0.1574
Echinococcus granulosus	rhodopsin orphan GPCR	0.0107	0.3639	0.1574
Brugia malayi	ORL1-like opioid receptor	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0107	0.3639	0.3639
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0107	0.3639	0.3639
Echinococcus multilocularis	nmda type glutamate receptor	0.0106	0.3536	0.3536
Schistosoma mansoni	glutamate receptor NMDA	0.0145	0.7659	1
Onchocerca volvulus		0.0107	0.3639	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0107	0.3639	0.1574
Echinococcus multilocularis	nmda type glutamate receptor	0.0167	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0107	0.3639	0.3639
Brugia malayi	RE15519p	0.0107	0.3639	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0107	0.3639	0.1574
Echinococcus granulosus	G protein coupled receptor 139	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0107	0.3639	0.1574
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0107	0.3639	0.3639
Echinococcus multilocularis	neuropeptide s receptor	0.0107	0.3639	0.3639
Brugia malayi	Melatonin receptor type 1A	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0107	0.3639	0.3639
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0107	0.3639	0.1574
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0107	0.3639	0.3639
Brugia malayi	neuropeptide F receptor	0.0107	0.3639	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0107	0.3639	0.1574
Brugia malayi	follicle stimulating hormone receptor	0.0107	0.3639	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0107	0.3639	0.3639
Echinococcus granulosus	orexin receptor type 2	0.0107	0.3639	0.1574
Echinococcus granulosus	biogenic amine 5HT receptor	0.0107	0.3639	0.1574
Echinococcus granulosus	7tm_1 domain containing protein	0.0107	0.3639	0.1574
Echinococcus multilocularis	g protein coupled receptor	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0107	0.3639	0.3639
Echinococcus granulosus	neuropeptides capa receptor	0.0107	0.3639	0.1574
Loa Loa (eye worm)	neuropeptide F receptor	0.0107	0.3639	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0107	0.3639	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0107	0.3639	0.3639
Echinococcus multilocularis	g-protein coupled receptor	0.0107	0.3639	0.3639
Echinococcus multilocularis	neuropeptide Y receptor	0.0107	0.3639	0.3639
Echinococcus granulosus	neuropeptide FF receptor 2	0.0107	0.3639	0.1574
Brugia malayi	Dopamine receptor	0.0107	0.3639	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0107	0.3639	0.3639
Onchocerca volvulus		0.0107	0.3639	0.5
Echinococcus granulosus	neuropeptide receptor	0.0107	0.3639	0.1574
Echinococcus granulosus	rhodopsin orphan GPCR	0.0107	0.3639	0.1574
Loa Loa (eye worm)	G-protein coupled receptor	0.0107	0.3639	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0107	0.3639	0.3639
Echinococcus multilocularis	orexin receptor type 2	0.0107	0.3639	0.3639
Onchocerca volvulus		0.0107	0.3639	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	somatostatin receptor	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0107	0.3639	0.1574
Echinococcus granulosus	neuropeptide s receptor	0.0107	0.3639	0.1574
Brugia malayi	neuropeptide F receptor	0.0107	0.3639	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	G protein-coupled receptor	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	Serotonin receptor	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0107	0.3639	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0107	0.3639	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0107	0.3639	0.3639
Echinococcus multilocularis	g protein coupled receptor	0.0107	0.3639	0.3639
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0107	0.3639	0.3639
Echinococcus granulosus	dro:myosuppressin receptor	0.0107	0.3639	0.1574
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0107	0.3639	0.5
Echinococcus granulosus	serotonin receptor	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0107	0.3639	0.5
Echinococcus granulosus	g protein coupled receptor	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0107	0.3639	0.3639
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0107	0.3639	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	serotonin receptor	0.0107	0.3639	0.3639
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0107	0.3639	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0107	0.3639	0.3639
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0107	0.3639	0.3639
Brugia malayi	putative neuropeptide receptor	0.0107	0.3639	0.5
Echinococcus multilocularis	serotonin receptor	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0107	0.3639	0.1574
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0107	0.3639	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Echinococcus granulosus	neuropeptide receptor	0.0107	0.3639	0.1574
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	g protein coupled receptor	0.0107	0.3639	0.1574
Echinococcus granulosus	rhodopsin orphan GPCR	0.0107	0.3639	0.1574
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0107	0.3639	0.3639
Onchocerca volvulus		0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	nmda type glutamate receptor	0.0106	0.3536	0.1439
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0107	0.3639	0.3639
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0107	0.3639	0.1574
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0107	0.3639	0.1574
Onchocerca volvulus		0.0107	0.3639	0.5
Brugia malayi	AKH receptor	0.0107	0.3639	0.5
Brugia malayi	G-protein coupled receptor	0.0107	0.3639	0.5
Brugia malayi	Serotonin receptor	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Brugia malayi	GnHR receptor homolog	0.0107	0.3639	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0107	0.3639	0.3639
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Brugia malayi	G-protein coupled receptor	0.0107	0.3639	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0107	0.3639	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0107	0.3639	0.3639
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0107	0.3639	0.5
Onchocerca volvulus		0.0107	0.3639	0.5
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0107	0.3639	0.3639
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0107	0.3639	0.3639
Echinococcus granulosus	biogenic amine 5HT receptor	0.0107	0.3639	0.1574
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0107	0.3639	0.1574
Echinococcus granulosus	neuropeptide Y receptor	0.0107	0.3639	0.1574
Echinococcus granulosus	hypothetical protein	0.0107	0.3639	0.1574
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0107	0.3639	0.3639
Loa Loa (eye worm)	G-protein coupled receptor	0.0107	0.3639	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0107	0.3639	0.1574
Echinococcus granulosus	rhodopsin orphan GPCR	0.0107	0.3639	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	glutamate receptor NMDA	0.0095	0.245	0.245
Echinococcus granulosus	allatostatin A receptor	0.0107	0.3639	0.1574
Onchocerca volvulus		0.0107	0.3639	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0107	0.3639	0.3639
Echinococcus multilocularis	g protein coupled receptor	0.0107	0.3639	0.3639
Echinococcus multilocularis	G protein coupled receptor 139	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	sex peptide receptor	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0107	0.3639	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	sulfakinin receptor protein	0.0107	0.3639	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0107	0.3639	0.3639
Brugia malayi	G protein-coupled receptor F59B2.13	0.0107	0.3639	0.5
Echinococcus multilocularis	somatostatin receptor	0.0107	0.3639	0.3639
Echinococcus granulosus	sex peptide receptor	0.0107	0.3639	0.1574
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Brugia malayi	hypothetical protein	0.0107	0.3639	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0107	0.3639	0.3639
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3639	0.5
Echinococcus granulosus	g protein coupled receptor	0.0107	0.3639	0.1574
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0107	0.3639	0.3639
Brugia malayi	Dopamine receptor protein 1	0.0107	0.3639	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 10 uM	Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA.	ChEMBL.	1382133
Ki (binding)	> 10 uM	Displacement of [3H]-glycine from glycine site on the NMDA receptor.	ChEMBL.	1382133
Ki (binding)	> 10 uM	Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA.	ChEMBL.	1382133
Ki (binding)	> 10 uM	Displacement of [3H]-glycine from glycine site on the NMDA receptor.	ChEMBL.	1382133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL325557
PubChem: 10358802

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 187084