Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endoplasmic reticulum aminopeptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Peptidase family M1 containing protein | endoplasmic reticulum aminopeptidase 1 | 941 aa | 846 aa | 29.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0042 | 0.1992 | 0.1383 |
Echinococcus granulosus | aminopeptidase N | 0.0042 | 0.1992 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0042 | 0.1992 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0088 | 0.5843 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1683 | 0.5303 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0844 | 0.0101 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.3174 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0.1992 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.1383 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.8975 | 0.8892 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0844 | 0.5 |
Loa Loa (eye worm) | aminopeptidase N | 0.0042 | 0.1992 | 0.1342 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.3174 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0.1992 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0134 | 0.9725 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0042 | 0.1992 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.1992 | 0.5 | |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0042 | 0.1992 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1683 | 0.183 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0844 | 0.266 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0042 | 0.1992 | 0.2438 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.3174 | 0.262 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0042 | 0.1992 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0.1992 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0042 | 0.1992 | 0.6277 |
Brugia malayi | Peptidase family M1 containing protein | 0.0042 | 0.1992 | 0.6277 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0844 | 0.0752 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0.1992 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0844 | 0.0752 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.1383 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.1992 | 0.5 | |
Echinococcus multilocularis | aminopeptidase N | 0.0042 | 0.1992 | 0.1383 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0.1992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1683 | 0.1008 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0042 | 0.1992 | 0.2438 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0844 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.3174 | 0.262 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.1383 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1992 | 0.6277 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0844 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.1383 |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0.1992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.6117 | 0.5802 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.1383 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.1992 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0844 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0042 | 0.1992 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.1992 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | 12.97 uM | PubChem BioAssay. MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.