Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Saccharomyces cerevisiae | Rce1p | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | integral membrane protein | 0.0023 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1782 | 0.1755 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1782 | 0.0732 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0111 | 0.4831 | 0.417 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1134 | 0.2347 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0111 | 0.4831 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1134 | 0.2347 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1782 | 0.0732 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1134 | 0.2347 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0111 | 0.4831 | 0.417 |
Treponema pallidum | hypothetical protein | 0.0023 | 0 | 0.5 |
Chlamydia trachomatis | hypothetical protein | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0111 | 0.4831 | 0.417 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0111 | 0.4831 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0111 | 0.4831 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0111 | 0.4831 | 1 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0111 | 0.4831 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0111 | 0.4831 | 0.5 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0111 | 0.4831 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0111 | 0.4831 | 0.417 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0111 | 0.4831 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1782 | 0.0732 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1782 | 0.0732 |
Toxoplasma gondii | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.4831 | 1 |
Plasmodium vivax | protease, putative | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Plasmodium falciparum | protease, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1782 | 0.0732 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1782 | 0.0732 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1134 | 0.2347 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1782 | 0.0732 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 5.504 uM | PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
Potency (functional) | 1.1582 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.2387 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.5821 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.