Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
dP/dt20 (functional) | 0 mg kg-1 | In vivo index of cardiac contractility using paced guinea pig model; No estimate | ChEMBL. | 8230126 |
ED20 (functional) | = 0.2 mg kg-1 | Effective dose in vivo for cardiac refractoriness (ERP) using paced guinea pig model | ChEMBL. | 8230126 |
Inhibition (binding) | = 43 % | Percentage inhibition of specific binding of [3H]-dofetilide (UK-68,798) from cardiac myocytes with blockade of delayed rectifier K+ channel | ChEMBL. | 8230126 |
Inhibition (binding) | = 100 % | Percentage inhibition of specific binding of [3H]-batrachotoxin [3H]-BTX) in sodium channel from cardiac myocytes at 10 microM | ChEMBL. | 8230126 |
Inhibition (binding) | = 100 % | Percentage inhibition of specific binding of [3H]-batrachotoxin [3H]-BTX) in sodium channel from cardiac myocytes at 10 microM | ChEMBL. | 8230126 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.