Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0877 | 0.8533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.069 | 0.5828 | 0.683 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0288 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0288 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0978 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0288 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0288 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0288 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0288 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0288 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0288 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0288 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0288 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0791 | 0.7295 | 0.8549 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0288 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0288 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0288 | 0 | 0.5 |
Onchocerca volvulus | 0.0978 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0288 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0978 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BSI (binding) | = 3 | Binding selectivity index as the ratio of RBA value of the compound to that of NSB value. | ChEMBL. | 7830275 |
BSI (binding) | = 15 | Binding selectivity index as the ratio of RBA value of the compound to that of NSB value. | ChEMBL. | 7830275 |
BSI (binding) | = 3 | Binding selectivity index as the ratio of RBA value of the compound to that of NSB value. | ChEMBL. | 7830275 |
BSI (binding) | = 15 | Binding selectivity index as the ratio of RBA value of the compound to that of NSB value. | ChEMBL. | 7830275 |
logP (ADMET) | = 3.9 | Partition coefficient (logP) | ChEMBL. | 7830275 |
logP (ADMET) | = 4.23 | Partition coefficient (logP) | ChEMBL. | 7830275 |
NSB (binding) | = 0.86 | Nonspecfic binding affinity against progesterone receptor was estimated relative to compound R5020 | ChEMBL. | 7830275 |
NSB (binding) | = 1.2 | Nonspecfic binding affinity against progesterone receptor was estimated relative to compound R5020 | ChEMBL. | 7830275 |
NSB (binding) | = 0.86 | Nonspecfic binding affinity against progesterone receptor was estimated relative to compound R5020 | ChEMBL. | 7830275 |
NSB (binding) | = 1.2 | Nonspecfic binding affinity against progesterone receptor was estimated relative to compound R5020 | ChEMBL. | 7830275 |
RBA (binding) | = 3 | Relative binding affinity against progesterone receptor at 0 degree centigrade determined in a competitive radiometric binding assay (R5020=100%). | ChEMBL. | 7830275 |
RBA (binding) | = 13 | Relative binding affinity against progesterone receptor at 0 degree centigrade determined in a competitive radiometric binding assay (R5020=100%). | ChEMBL. | 7830275 |
RBA (binding) | = 3 | Relative binding affinity against progesterone receptor at 0 degree centigrade determined in a competitive radiometric binding assay (R5020=100%). | ChEMBL. | 7830275 |
RBA (binding) | = 13 | Relative binding affinity against progesterone receptor at 0 degree centigrade determined in a competitive radiometric binding assay (R5020=100%). | ChEMBL. | 7830275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.