Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0013 | 0.002 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0799 | 0.3338 | 0.5184 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0799 | 0.3338 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0315 | 0.0617 | 0.0958 |
Brugia malayi | hypothetical protein | 0.0925 | 0.4046 | 0.6284 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1983 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.135 | 0.6439 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0013 | 0.002 |
Echinococcus multilocularis | geminin | 0.0291 | 0.0484 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0617 | 0.0958 |
Brugia malayi | Kringle domain containing protein | 0.0799 | 0.3338 | 0.5184 |
Loa Loa (eye worm) | trypsin family protein | 0.0208 | 0.0013 | 0.002 |
Onchocerca volvulus | 0.0315 | 0.0617 | 0.0939 | |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0315 | 0.0617 | 0.0604 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0799 | 0.3338 | 0.3329 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0315 | 0.0617 | 0.0604 |
Brugia malayi | Trypsin family protein | 0.0208 | 0.0013 | 0.002 |
Brugia malayi | Trypsin family protein | 0.0208 | 0.0013 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0617 | 0.0958 |
Onchocerca volvulus | 0.135 | 0.6439 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0799 | 0.3338 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0208 | 0.0013 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0925 | 0.4046 | 0.6284 |
Schistosoma mansoni | hypothetical protein | 0.0291 | 0.0484 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0013 | 0.002 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0208 | 0.0013 | 0.002 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0315 | 0.0617 | 0.0604 |
Brugia malayi | hypothetical protein | 0.0208 | 0.0013 | 0.002 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0315 | 0.0617 | 0.0939 |
Onchocerca volvulus | Deterin homolog | 0.0315 | 0.0617 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 0.6439 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0799 | 0.3338 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0799 | 0.3338 | 0.5174 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.135 | 0.6439 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0799 | 0.3338 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0925 | 0.4046 | 0.6284 |
Schistosoma mansoni | hypothetical protein | 0.0291 | 0.0484 | 0.0733 |
Mycobacterium ulcerans | hypothetical protein | 0.0208 | 0.0013 | 0.5 |
Brugia malayi | Trypsin family protein | 0.135 | 0.6439 | 1 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0315 | 0.0617 | 0.0604 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.0617 | 0.0939 |
Echinococcus granulosus | geminin | 0.0291 | 0.0484 | 0.0472 |
Onchocerca volvulus | 0.1142 | 0.5271 | 0.8183 | |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 0.6439 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0315 | 0.0617 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0799 | 0.3338 | 0.5184 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0799 | 0.3338 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0799 | 0.3338 | 0.3329 |
Brugia malayi | Trypsin family protein | 0.0208 | 0.0013 | 0.002 |
Brugia malayi | Protein kinase domain containing protein | 0.0799 | 0.3338 | 0.5184 |
Onchocerca volvulus | 0.0799 | 0.3338 | 0.5174 | |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0013 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0013 | 0.002 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0315 | 0.0617 | 0.0939 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.