Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | replication protein A1, 70kDa | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0145 | 0.5869 | 0.5625 |
Onchocerca volvulus | 0.0034 | 0.0651 | 0.0097 | |
Toxoplasma gondii | microneme protein MIC4 | 0.0032 | 0.0559 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5869 | 0.5625 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0651 | 0.0097 |
Trypanosoma brucei | Replication factor A protein 1 | 0.002 | 0 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0034 | 0.0651 | 0.0097 |
Toxoplasma gondii | microneme protein MIC17A | 0.0032 | 0.0559 | 0.0952 |
Trichomonas vaginalis | replication factor A 1, rfa1, putative | 0.0042 | 0.1035 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0145 | 0.5869 | 1 |
Toxoplasma gondii | microneme protein MIC17B | 0.0032 | 0.0559 | 0.0952 |
Schistosoma mansoni | replication factor A 1 rfa1 | 0.0042 | 0.1035 | 0.0411 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0145 | 0.5869 | 1 |
Brugia malayi | Trypsin family protein | 0.0034 | 0.0651 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 1 | 1 |
Onchocerca volvulus | Putative replication factor A 73 kDa subunit | 0.0038 | 0.0826 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0651 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0651 | 0.0097 |
Toxoplasma gondii | PAN domain-containing protein | 0.0032 | 0.0559 | 0.0952 |
Onchocerca volvulus | 0.0199 | 0.8397 | 0.8302 | |
Onchocerca volvulus | 0.0034 | 0.0651 | 0.0097 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0233 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0145 | 0.5869 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0032 | 0.0559 | 0.0952 |
Loa Loa (eye worm) | trypsin family protein | 0.0034 | 0.0651 | 0.0097 |
Toxoplasma gondii | PAN domain-containing protein | 0.0032 | 0.0559 | 0.0952 |
Trichomonas vaginalis | replication factor A 1, rfa1, putative | 0.0042 | 0.1035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0651 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0032 | 0.0559 | 0.0952 |
Brugia malayi | replication factor A 73 kDa subunit | 0.0042 | 0.1035 | 0.0504 |
Echinococcus multilocularis | replication protein A 70 kDa DNA binding | 0.0042 | 0.1035 | 0.0736 |
Toxoplasma gondii | hypothetical protein | 0.0032 | 0.0559 | 0.0952 |
Brugia malayi | Trypsin family protein | 0.0034 | 0.0651 | 0.0097 |
Leishmania major | hypothetical protein, conserved | 0.0145 | 0.5869 | 1 |
Onchocerca volvulus | 0.0233 | 1 | 1 | |
Onchocerca volvulus | 0.0034 | 0.0651 | 0.0097 | |
Brugia malayi | hypothetical protein | 0.0034 | 0.0651 | 0.0097 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0233 | 1 | 1 |
Echinococcus granulosus | replication protein A 70 kDa DNA binding | 0.0042 | 0.1035 | 0.0736 |
Onchocerca volvulus | 0.0145 | 0.5869 | 0.5625 | |
Toxoplasma gondii | microneme protein MIC17C | 0.0032 | 0.0559 | 0.0952 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0145 | 0.5869 | 1 |
Onchocerca volvulus | 0.0034 | 0.0651 | 0.0097 | |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0145 | 0.5869 | 0.5625 |
Toxoplasma gondii | subtilisin SUB12 | 0.0032 | 0.0559 | 0.0952 |
Brugia malayi | Trypsin family protein | 0.0034 | 0.0651 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.5869 | 0.5582 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0651 | 0.0097 |
Toxoplasma gondii | PAN domain-containing protein | 0.0032 | 0.0559 | 0.0952 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0034 | 0.0651 | 0.0097 |
Mycobacterium ulcerans | hypothetical protein | 0.0034 | 0.0651 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0651 | 0.0097 | |
Toxoplasma gondii | 1,3(4)-beta-glucanase | 0.0032 | 0.0559 | 0.0952 |
Brugia malayi | Kringle domain containing protein | 0.0145 | 0.5869 | 0.5625 |
Loa Loa (eye worm) | replication factor A 73 kDa subunit | 0.0042 | 0.1035 | 0.0504 |
Toxoplasma gondii | PAN domain-containing protein | 0.0032 | 0.0559 | 0.0952 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0145 | 0.5869 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0145 | 0.5869 | 1 |
Trichomonas vaginalis | replication factor A 1, rfa1, putative | 0.004 | 0.0937 | 0.9053 |
Toxoplasma gondii | microneme protein, putative | 0.0032 | 0.0559 | 0.0952 |
Toxoplasma gondii | PAN/Apple domain-containing protein | 0.0032 | 0.0559 | 0.0952 |
Toxoplasma gondii | PAN domain-containing protein | 0.0032 | 0.0559 | 0.0952 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 0.91 uM | Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarization anisotropy assay | ChEMBL. | 24491171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.