Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prolylcarboxypeptidase (angiotensinase C) | Starlite/ChEMBL | References |
Homo sapiens | prolylcarboxypeptidase (angiotensinase C) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | prolylcarboxypeptidase (angiotensinase C) | 496 aa | 414 aa | 24.1 % |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | prolylcarboxypeptidase (angiotensinase C) | 491 aa | 402 aa | 24.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0636 | 1 | 0.5 |
Brugia malayi | Muscle positioning protein 4 | 0.0238 | 0.136 | 0.1185 |
Brugia malayi | Kringle domain containing protein | 0.0636 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.136 | 0.1185 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0225 | 0.1082 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.1082 | 0.0901 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0636 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0636 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0636 | 1 | 1 |
Brugia malayi | Serine carboxypeptidase S28 family protein | 0.0225 | 0.1082 | 0.0901 |
Onchocerca volvulus | 0.0636 | 1 | 1 | |
Toxoplasma gondii | kringle domain-containing protein | 0.0636 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0636 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0208 | 0.0725 | 0.0725 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0222 | 0.0024 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0636 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0636 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.1082 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.1082 | 0.0901 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0198 | 0.0198 |
Onchocerca volvulus | 0.0238 | 0.136 | 0.1185 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0636 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.7 nM | Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by continuous fluorometric assay | ChEMBL. | 24636945 |
IC50 (binding) | = 10.4 nM | Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by continuous fluorometric assay | ChEMBL. | 24636945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.