Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacteria | Bacterial dihydropteroate synthase | Starlite/ChEMBL | References |
Staphylococcus aureus | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Get druggable targets OG5_133110 | All targets in OG5_133110 |
Mycobacterium leprae | Probable2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin | Get druggable targets OG5_133110 | All targets in OG5_133110 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | Get druggable targets OG5_133110 | All targets in OG5_133110 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 0.0541 | 0 | 0.5 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | 0.0882 | 0.5646 | 0.5 |
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 0.0541 | 0 | 0.5 |
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 0.1145 | 1 | 0.5 |
Chlamydia trachomatis | bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase | 0.0541 | 0 | 0.5 |
Toxoplasma gondii | dihydropteroate synthase | 0.0541 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 12 % | Inhibition of GST-tagged Escherichia coli HPPK expressed in Escherichia coli using 6-hydroxymethyl-7,8-dihydropterin hydrochloride as substrate at 250 uM after 20 mins by luminescence assay | ChEMBL. | 24613625 |
Kd (binding) | = 1.6 uM | Binding affinity to Escherichia coli DHPS by surface plasmon resonance analysis | ChEMBL. | 25357262 |
Kd (binding) | = 2.8 uM | Binding affinity to Staphylococcus aureus recombinant HPPK by surface plasmon resonance analysis in presence of ATP | ChEMBL. | 25357262 |
Kd (binding) | = 21.7 uM | Binding affinity to Staphylococcus aureus recombinant HPPK by surface plasmon resonance analysis | ChEMBL. | 25357262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.