Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.1127 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.1127 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.1127 | 1 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0288 | 0.2465 | 0.2465 |
Schistosoma mansoni | high-affinity choline transporter | 0.0288 | 0.2465 | 0.2465 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0288 | 0.2465 | 0.2465 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.1127 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0013 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.1127 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.2465 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0288 | 0.2465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.2465 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0288 | 0.2465 | 0.2465 |
Schistosoma mansoni | sodium/solute symporter | 0.0288 | 0.2465 | 0.2465 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.1127 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0288 | 0.2465 | 1 |
Onchocerca volvulus | 0.0288 | 0.2465 | 1 | |
Brugia malayi | GH02984p | 0.0288 | 0.2465 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.1127 | 1 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0288 | 0.2465 | 0.2465 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.1127 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 nM | Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum free buffer incubated for 20 mins prior to p53 addition measured after 60 mins by HTRF assay | ChEMBL. | 24601644 |
IC50 (functional) | = 247 nM | Cytotoxicity against human SJSA1 cells assessed as growth inhibition after 16 hrs by EdU incorporation assay in presence of 10% human serum | ChEMBL. | 24601644 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24601644 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.