Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Homo sapiens | phosphorylase, glycogen | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glutaminase, putative | 0.0273 | 0.8947 | 0.4011 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0143 | 0.1674 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0261 | 0.8242 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0261 | 0.8242 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.8947 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0143 | 0.1674 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0261 | 0.8242 | 0.8242 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0261 | 0.8242 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0292 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.8947 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0261 | 0.8242 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0261 | 0.8242 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0261 | 0.8242 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0292 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0261 | 0.8242 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.8947 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0261 | 0.8242 | 0.8242 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.8947 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0261 | 0.8242 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0273 | 0.8947 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0261 | 0.8242 | 0.9212 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0143 | 0.1674 | 0.1871 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0261 | 0.8242 | 0.9212 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.5 uM | In vitro inhibition of glucagon-stimulated glycogenolysis in primary rat hepatocytes | ChEMBL. | 14505637 |
IC50 (binding) | = 395 nM | In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa) | ChEMBL. | 14505637 |
IC50 (binding) | = 395 nM | In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa) | ChEMBL. | 14505637 |
IC50 (binding) | = 1195 nM | In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa) | ChEMBL. | 14505637 |
IC50 (binding) | = 1195 nM | In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa) | ChEMBL. | 14505637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.