Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0139 | 0.1045 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.018 | 0.1438 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0038 | 0.0074 | 0.0086 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0038 | 0.0074 | 0.0086 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0056 | 0.0245 | 0.0171 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0038 | 0.0074 | 0.0086 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0139 | 0.1045 | 0.6532 |
Entamoeba histolytica | kinesin, putative | 0.0139 | 0.1045 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0056 | 0.0245 | 0.1145 |
Plasmodium vivax | kinesin-5 | 0.0139 | 0.1045 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0038 | 0.0074 | 0.0086 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0056 | 0.0245 | 0.0282 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0192 | 0.156 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0139 | 0.1045 | 0.1206 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0038 | 0.0074 | 0.0086 |
Giardia lamblia | Kinesin-5 | 0.0139 | 0.1045 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.018 | 0.1438 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0139 | 0.1045 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0192 | 0.156 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0929 | 0.8663 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0192 | 0.156 | 0.1497 |
Schistosoma mansoni | voltage-gated potassium channel | 0.021 | 0.1731 | 0.1998 |
Schistosoma mansoni | voltage-gated potassium channel | 0.021 | 0.1731 | 0.1998 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0245 | 0.1145 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0056 | 0.0245 | 0.0171 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0056 | 0.0245 | 0.0171 |
Echinococcus granulosus | voltage gated potassium channel | 0.0056 | 0.0245 | 0.0171 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0038 | 0.0074 | 0.0086 |
Echinococcus multilocularis | kinesin family 1 | 0.1068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1316 | 0.8354 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0056 | 0.0245 | 0.0282 |
Brugia malayi | Kinesin motor domain containing protein | 0.0139 | 0.1045 | 0.6532 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0192 | 0.156 | 0.1497 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 79 % | Potentiation of rat recombinant GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response at 30 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 24512267 |
Activity (binding) | = 87 % | Potentiation of rat recombinant GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response at 30 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 24512267 |
Activity (binding) | = 93 % | Potentiation of rat recombinant GluN1/GluN2B expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response at 30 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 24512267 |
Activity (binding) | = 129 % | Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response at 30 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 24512267 |
EC50 (binding) | = 52 uM | Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response by two-electrode voltage clamp technique relative to control | ChEMBL. | 24512267 |
max activation (binding) | = 187 % | Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response at 30 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 24512267 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.