Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.1661 | 1 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.1455 | 0.8427 | 0.8427 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0557 | 0.1573 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1661 | 1 | 1 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.1455 | 0.8427 | 0.8427 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0557 | 0.1573 | 0.1573 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.1661 | 1 | 1 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.1661 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 100 mg kg-1 | Effect on pupil dilation was measured in mice upon oral administration | ChEMBL. | 7265119 |
ED50 (functional) | = 100 mg kg-1 | Effect on pupil dilation was measured in mice upon oral administration | ChEMBL. | 7265119 |
ED50 (functional) | > 125 mg kg-1 | Antidepressant activity by determining the reversal of tetrabenazine-induced ptosis upon oral administration | ChEMBL. | 7265119 |
ED50 (functional) | > 125 mg kg-1 | Antidepressant activity by determining the decreased exploratory activity in mice upon oral administration | ChEMBL. | 7265119 |
ED50 (functional) | > 125 mg kg-1 | Antidepressant activity by determining the reversal of tetrabenazine-induced ptosis upon oral administration | ChEMBL. | 7265119 |
ED50 (functional) | > 125 mg kg-1 | Antidepressant activity by determining the decreased exploratory activity in mice upon oral administration | ChEMBL. | 7265119 |
ED50 (functional) | = 200 mg kg-1 | The effect of the compound on ataxia was measured in mice upon ip administration | ChEMBL. | 7265119 |
ED50 (functional) | = 200 mg kg-1 | The effect of the compound on ataxia was measured in mice upon ip administration | ChEMBL. | 7265119 |
ED50 (functional) | = 300 mg kg-1 | The effect of the compound on electroshock protection was measured in mice upon ip administration | ChEMBL. | 7265119 |
ED50 (functional) | = 300 mg kg-1 | The effect of the compound on 24-hour mortality was measured in mice upon ip administration | ChEMBL. | 7265119 |
ED50 (functional) | = 300 mg kg-1 | The effect of the compound on electroshock protection was measured in mice upon ip administration | ChEMBL. | 7265119 |
ED50 (functional) | = 300 mg kg-1 | The effect of the compound on 24-hour mortality was measured in mice upon ip administration | ChEMBL. | 7265119 |
ED50 (functional) | > 324 mg kg-1 | The effect of the compound on excitement was measured in mice upon ip administration | ChEMBL. | 7265119 |
ED50 (functional) | > 324 mg kg-1 | The effect of the compound on excitement was measured in mice upon ip administration | ChEMBL. | 7265119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.