TDR Targets

Basic information

Technical information

TDR Targets ID: 188824
Name: 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1H- indazole
MW: 329.438 | Formula: C22H23N3
H donors: 1 H acceptors: 1 LogP: 4.48 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)CC1CCN(CC1)CC#Cc1ccc2c(c1)cn[nH]2
InChi: 1S/C22H23N3/c1-2-5-18(6-3-1)15-20-10-13-25(14-11-20)12-4-7-19-8-9-22-21(16-19)17-23-24-22/h1-3,5-6,8-9,16-17,20H,10-15H2,(H,23,24)
InChiKey: KIDRVLWOPFGWLW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[3-(4-benzyl-1-piperidyl)prop-1-ynyl]-1H-indazole
5-[3-(4-benzyl-1-piperidinyl)prop-1-ynyl]-1H-indazole
5-[3-[4-(phenylmethyl)piperidin-1-yl]prop-1-ynyl]-1H-indazole
5-[3-(4-benzylpiperidino)prop-1-ynyl]-1H-indazole
5-[3-[4-(phenylmethyl)-1-piperidyl]prop-1-ynyl]-1H-indazole
5-[3-[4-(phenylmethyl)-1-piperidinyl]prop-1-ynyl]-1H-indazole
5-[3-[4-(benzyl)-1-piperidyl]prop-1-ynyl]-1H-indazole

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, ionotropic, N-methyl D-aspartate 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0048	0.2019	0.5
Echinococcus granulosus	g protein coupled receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	neuropeptide F receptor	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0048	0.2019	0.5
Brugia malayi	GnHR receptor homolog	0.0048	0.2019	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0048	0.2019	0.2551
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Loa Loa (eye worm)	melatonin receptor type 1A	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.2019	0.2551
Brugia malayi	RE15519p	0.0048	0.2019	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	TYRA-2 protein	0.0048	0.2019	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0048	0.2019	0.2551
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.2019	0.2551
Echinococcus multilocularis	neuropeptide receptor A26	0.0048	0.2019	0.2551
Brugia malayi	G-protein coupled receptor	0.0048	0.2019	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0048	0.2019	0.2551
Echinococcus granulosus	glutamate receptor NMDA	0.0095	0.6972	0.881
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Echinococcus multilocularis	sex peptide receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.2019	0.2551
Echinococcus multilocularis	serotonin receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	allatostatin A receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	neuropeptide receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	nmda type glutamate receptor	0.01	0.7455	0.942
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	Serotonin receptor	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Brugia malayi	putative neuropeptide receptor	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0048	0.2019	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	g protein coupled receptor	0.0048	0.2019	0.2551
Onchocerca volvulus		0.0048	0.2019	0.5
Echinococcus granulosus	g protein coupled receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.2019	0.2551
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.2019	0.2551
Brugia malayi	Serotonin receptor	0.0048	0.2019	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0048	0.2019	0.5
Brugia malayi	AKH receptor	0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Echinococcus multilocularis	serotonin receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	larval opioid receptor	0.0048	0.2019	0.5
Echinococcus multilocularis	nmda type glutamate receptor	0.0104	0.7914	1
Echinococcus granulosus	somatostatin receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	somatostatin receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0048	0.2019	0.2551
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0048	0.2019	0.5
Echinococcus granulosus	hypothetical protein	0.0048	0.2019	0.2551
Onchocerca volvulus		0.0048	0.2019	0.5
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0048	0.2019	0.2551
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Brugia malayi	ORL1-like opioid receptor	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	Melatonin receptor type 1A	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	sulfakinin receptor protein	0.0048	0.2019	0.5
Echinococcus granulosus	sex peptide receptor	0.0048	0.2019	0.2551
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0048	0.2019	0.5
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0048	0.2019	0.2551
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	neuropeptide s receptor	0.0048	0.2019	0.2551
Brugia malayi	Dopamine receptor protein 1	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	Dopamine receptor protein 2	0.0048	0.2019	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0048	0.2019	0.2551
Onchocerca volvulus		0.0048	0.2019	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.2019	0.2551
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.2019	0.2551
Brugia malayi	follicle stimulating hormone receptor	0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	allatostatin A receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	neuropeptide s receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0048	0.2019	0.2551
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0048	0.2019	0.2551
Onchocerca volvulus		0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0048	0.2019	0.2551
Onchocerca volvulus		0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0048	0.2019	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	orexin receptor type 2	0.0048	0.2019	0.2551
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0048	0.2019	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.2019	0.5
Echinococcus multilocularis	glutamate receptor NMDA	0.0095	0.6972	0.881
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	neuropeptide FF receptor 2	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.2019	0.2551
Echinococcus granulosus	neuropeptide receptor A26	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	serotonin receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.2019	0.2551
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0048	0.2019	0.2551
Onchocerca volvulus		0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.2019	0.5
Brugia malayi	G protein-coupled receptor	0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.2019	0.2551
Onchocerca volvulus		0.0048	0.2019	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.2019	0.5
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0048	0.2019	0.5
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Echinococcus multilocularis	orexin receptor type 2	0.0048	0.2019	0.2551
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.2019	0.2551
Brugia malayi	putative neuropeptide receptor NPR1	0.0048	0.2019	0.5
Echinococcus granulosus	fmrfamide receptor	0.0048	0.2019	0.2551
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Echinococcus granulosus	G protein coupled receptor 139	0.0048	0.2019	0.2551
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0048	0.2019	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0048	0.2019	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0048	0.2019	0.2551
Onchocerca volvulus		0.0048	0.2019	0.5
Brugia malayi	G-protein coupled receptor	0.0048	0.2019	0.5
Brugia malayi	neuropeptide F receptor	0.0048	0.2019	0.5
Brugia malayi	Dopamine receptor	0.0048	0.2019	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0048	0.2019	0.2551
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0048	0.2019	0.5
Onchocerca volvulus		0.0048	0.2019	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0048	0.2019	0.2551
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.2019	0.2551
Echinococcus multilocularis	nmda type glutamate receptor	0.01	0.7455	0.942
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2019	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0048	0.2019	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.2019	0.2551
Echinococcus granulosus	nmda type glutamate receptor	0.0104	0.7914	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Brugia malayi	hypothetical protein	0.0048	0.2019	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0048	0.2019	0.2551
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.2019	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.2019	0.2551
Echinococcus granulosus	neuropeptide receptor	0.0048	0.2019	0.2551
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.2019	0.2551

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.38 uM	Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes	ChEMBL.	10978188
IC50 (binding)	= 0.38 uM	Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes	ChEMBL.	10978188
IC50 (binding)	> 100 uM	Concentration required for 50% Inhibition of responses at cloned NR1A/2A NMDA expressed in Xenopus oocytes	ChEMBL.	10978188
IC50 (binding)	> 100 uM	Concentration required for 50% Inhibition of responses at cloned NR1A/2C NMDA expressed in Xenopus oocytes	ChEMBL.	10978188
IC50 (binding)	> 100 uM	Concentration required for 50% Inhibition of responses at cloned NR1A/2A NMDA expressed in Xenopus oocytes	ChEMBL.	10978188
IC50 (binding)	> 100 uM	Concentration required for 50% Inhibition of responses at cloned NR1A/2C NMDA expressed in Xenopus oocytes	ChEMBL.	10978188

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL114644
PubChem: 10758743

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 188824