Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dna polymerase eta | 0.0052 | 0.3852 | 0.236 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0077 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0077 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0077 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0052 | 0.3852 | 0.3852 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0077 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0077 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0052 | 0.3852 | 0.236 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0077 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0052 | 0.3852 | 0.3852 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0077 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.