Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | plasmepsin VI | 0.00502389 | 0.187404 | 0.5 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0058868 | 0.259037 | 0.842442 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.00388511 | 0.0928701 | 0.157558 |
Echinococcus multilocularis | tyrosine kinase | 0.00358092 | 0.0676177 | 0.0534752 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.00502389 | 0.187404 | 0.140434 |
Leishmania major | extracellular receptor, putative | 0.00342463 | 0.0546435 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00358092 | 0.0676177 | 0.0534752 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.00502389 | 0.187404 | 0.547194 |
Onchocerca volvulus | 0.00388511 | 0.0928701 | 0.157558 | |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.00502389 | 0.187404 | 0.547194 |
Schistosoma mansoni | tyrosine kinase | 0.00358092 | 0.0676177 | 0.0137241 |
Plasmodium falciparum | plasmepsin IV | 0.00502389 | 0.187404 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.00634729 | 0.297263 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.00502389 | 0.187404 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.00502389 | 0.187404 | 0.547194 |
Schistosoma mansoni | tyrosine kinase | 0.00358092 | 0.0676177 | 0.0137241 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.00634729 | 0.297263 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.00502389 | 0.187404 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00502389 | 0.187404 | 0.547194 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0148127 | 1 | 1 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.00634729 | 0.297263 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.00634729 | 0.297263 | 1 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.00634729 | 0.297263 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.00502389 | 0.187404 | 0.5 |
Trypanosoma cruzi | extracellular receptor, putative | 0.00342463 | 0.0546435 | 0.5 |
Schistosoma mansoni | protein kinase | 0.00634729 | 0.297263 | 0.256644 |
Plasmodium falciparum | plasmepsin II | 0.00502389 | 0.187404 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.00502389 | 0.187404 | 0.5 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.00388511 | 0.0928701 | 0.157558 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0148127 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.00358092 | 0.0676177 | 0.0534752 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0058868 | 0.259037 | 0.842442 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.00502389 | 0.187404 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.00502389 | 0.187404 | 0.5 |
Mycobacterium ulcerans | adenylylate/guanylate cyclase | 0.00276637 | 0 | 0.5 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.00634729 | 0.297263 | 1 |
Entamoeba histolytica | hypothetical protein | 0.00342463 | 0.0546435 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.4 uM | Antiplasmodial activity against ring stage Plasmodium falciparum 3D7A infected in erythrocytes incubated for 24 hrs prior to [3H]hypoxanthine incorporation measured after 24 hrs | ChEMBL. | 24944739 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 24944739 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.