Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Onchocerca volvulus | |
References | |
Onchocerca volvulus | Chitinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | conserved protein, unknown function | 0.0144 | 1 | 0.5 |
Brugia malayi | Endochitinase | 0.0102 | 0.3645 | 0.2052 |
Mycobacterium tuberculosis | Possible chitinase | 0.0078 | 0 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0144 | 1 | 0.5 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0144 | 1 | 0.5 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0091 | 0.2004 | 0.2004 |
Onchocerca volvulus | 0.0144 | 1 | 1 | |
Entamoeba histolytica | chitinase, putative | 0.0091 | 0.2004 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0102 | 0.3645 | 0.2052 |
Onchocerca volvulus | Putative endochitinase | 0.0102 | 0.3645 | 0.2052 |
Toxoplasma gondii | hypothetical protein | 0.0144 | 1 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0102 | 0.3645 | 0.2052 |
Brugia malayi | endochitinase | 0.0102 | 0.3645 | 0.2052 |
Plasmodium vivax | hypothetical protein, conserved | 0.0144 | 1 | 0.5 |
Loa Loa (eye worm) | chitinase I | 0.0091 | 0.2004 | 0.2004 |
Leishmania major | chitinase | 0.0091 | 0.2004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 1 | 0.5 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0088 | 0.1641 | 0.1641 |
Onchocerca volvulus | 0.0144 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | Drug accumulation in Caenorhabditis elegans at 10 uM after 6 hrs by LC-MS analysis | ChEMBL. | 24918716 | |
IC50 (binding) | = 0.6 uM | Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by microplate reader analysis | ChEMBL. | 24918716 |
Inhibition (functional) | Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 100 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC | ChEMBL. | 24918716 | |
Inhibition (binding) | Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate at 10 uM after 10 mins by microplate reader analysis | ChEMBL. | 24918716 | |
Inhibition (functional) | Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 0.5 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC and 0.5 uM protonophore CCCP | ChEMBL. | 24918716 | |
Inhibition (functional) | Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 2.5 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC and 2.5 uM protonophore CCCP | ChEMBL. | 24918716 | |
Inhibition (functional) | Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 10 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC | ChEMBL. | 24918716 | |
Inhibition (functional) | Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 1 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC and 1 uM protonophore CCCP | ChEMBL. | 24918716 | |
Inhibition (functional) | Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 1 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC | ChEMBL. | 24918716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.