Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0441 | 1 | 0.5 | |
Onchocerca volvulus | 0.0441 | 1 | 0.5 | |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0384 | 0 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0384 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0384 | 0 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0441 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 2.5 /min | Induction of electric eel AChE phosphorylation | ChEMBL. | 950651 |
K (binding) | = 3.3 10'-3M | Binding affinity to electric eel AChE | ChEMBL. | 950651 |
Ki (binding) | = 0.8 10'3/M/min | Inhibition of electric eel AChE assessed as decrease in thiophenol formation using acetylthiocholine as substrate by Ellman's method | ChEMBL. | 950651 |
LD50 (ADMET) | = 190 mg kg-1 | Acute toxicity in sc dosed Ness-Ziona mouse assessed as mortality after 24 hrs | ChEMBL. | 950651 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.