TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 386.446 | Formula: C23H22N4O2
H donors: 1 H acceptors: 2 LogP: 2.8 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccn2c1nc1cc3ccccc3cc1c2=O)NCCN1CCCC1
InChi: 1S/C23H22N4O2/c28-22(24-9-13-26-10-3-4-11-26)18-8-5-12-27-21(18)25-20-15-17-7-2-1-6-16(17)14-19(20)23(27)29/h1-2,5-8,12,14-15H,3-4,9-11,13H2,(H,24,28)
InChiKey: QTAFSEJFKCZGEE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (RNA) I polypeptide A, 194kDa	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Schistosoma japonicum	DNA-directed RNA polymerase I subunit RPA1, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Plasmodium falciparum	RNA polymerase I	Get druggable targets OG5_127924	All targets in OG5_127924
Trypanosoma cruzi	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Cryptosporidium hominis	DNA-directed RNA polymerase	Get druggable targets OG5_127924	All targets in OG5_127924
Trypanosoma congolense	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Schistosoma japonicum	DNA-directed RNA polymerase I subunit RPA1, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Candida albicans	RNA polymerase I largest subunit	Get druggable targets OG5_127924	All targets in OG5_127924
Plasmodium vivax	DNA-directed RNA polymerase I 190 kDa polypeptide, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Schistosoma japonicum	ko:K02999 DNA-directed RNA polymerase I subunit A1, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Plasmodium yoelii	RNA polymerase A/beta'/A'' subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Babesia bovis	DNA directed RNA polymerase	Get druggable targets OG5_127924	All targets in OG5_127924
Trichomonas vaginalis	RNA polymerase A, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Brugia malayi	RNA polymerase Rpb1, domain 2 family protein	Get druggable targets OG5_127924	All targets in OG5_127924
Echinococcus multilocularis	DNA directed RNA polymerase I subunit RPA1	Get druggable targets OG5_127924	All targets in OG5_127924
Cryptosporidium parvum	DNA-directed RNA polymerase I, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Candida albicans	RNA polymerase I largest subunit	Get druggable targets OG5_127924	All targets in OG5_127924
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127924	All targets in OG5_127924
Theileria parva	RNA polymerase large subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Entamoeba histolytica	DNA-directed RNA polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Leishmania mexicana	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Leishmania infantum	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Schistosoma japonicum	DNA-directed RNA polymerase I subunit rpa1, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Leishmania major	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Neospora caninum	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Trypanosoma brucei	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Echinococcus granulosus	DNA directed RNA polymerase I subunit RPA1	Get druggable targets OG5_127924	All targets in OG5_127924
Schistosoma japonicum	DNA-directed RNA polymerase I subunit RPA1, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Trypanosoma brucei gambiense	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Trypanosoma brucei	DNA-directed RNA polymerase I largest subunit	Get druggable targets OG5_127924	All targets in OG5_127924
Leishmania donovani	DNA-directed rna polymerase I largest subunit, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Toxoplasma gondii	DNA-directed RNA polymerase I RPA1	Get druggable targets OG5_127924	All targets in OG5_127924
Plasmodium knowlesi	RNA polymerase I, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Plasmodium berghei	RNA polymerase I, putative	Get druggable targets OG5_127924	All targets in OG5_127924
Schistosoma mansoni	DNA-directed RNA polymerase I	Get druggable targets OG5_127924	All targets in OG5_127924
Giardia lamblia	RNA polymerase AI large subunit	Get druggable targets OG5_127924	All targets in OG5_127924

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	RE15519p	0.0016	0.8248	0.7565
Schistosoma mansoni	neuropeptide receptor	0.0016	0.8248	0.7565
Brugia malayi	AKH receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	amine GPCR	0.0016	0.8248	0.7565
Brugia malayi	G-protein coupled receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.8248	0.9803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Schistosoma mansoni	neuropeptide f receptor 76f	0.0016	0.8248	0.7565
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus multilocularis	somatostatin receptor	0.0016	0.8248	0.9803
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Trypanosoma brucei	DNA-directed RNA polymerase I largest subunit	0.0016	0.8358	1
Brugia malayi	ORL1-like opioid receptor	0.0016	0.8248	0.7565
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0016	0.8248	0.7565
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.8248	0.9803
Echinococcus granulosus	sex peptide receptor	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	neuropeptide F receptor	0.0016	0.8248	0.7565
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0016	0.8248	0.5
Schistosoma mansoni	biogenic amine receptor	0.0016	0.8248	0.7565
Brugia malayi	Dopamine receptor protein 1	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.8248	0.7565
Brugia malayi	follicle stimulating hormone receptor	0.0016	0.8248	0.7565
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	adenoreceptor	0.0016	0.8248	0.7565
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.8248	0.7565
Brugia malayi	putative neuropeptide receptor	0.0016	0.8248	0.7565
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0016	0.8248	0.9803
Echinococcus multilocularis	serotonin receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Brugia malayi	Dopamine receptor	0.0016	0.8248	0.7565
Schistosoma mansoni	myosin xvIII	0.0016	0.8248	0.7565
Schistosoma mansoni	opsin-like receptor	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Trypanosoma brucei	RNA polymerase IIA largest subunit	0.0009	0.2808	0.336
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0016	0.8248	0.5
Echinococcus granulosus	allatostatin A receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0016	0.8248	0.7565
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	Serotonin receptor	0.0016	0.8248	0.7565
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.8248	0.9803
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0016	0.8248	0.9803
Echinococcus multilocularis	sex peptide receptor	0.0016	0.8248	0.9803
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	neuropeptide receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0016	0.8248	0.9803
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Trichomonas vaginalis	RNA polymerase A, putative	0.0016	0.8358	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.8248	0.9803
Echinococcus granulosus	g-protein coupled receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Plasmodium falciparum	RNA polymerase I	0.0018	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Echinococcus multilocularis	serotonin receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	somatostatin receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	neuropeptide receptor A26	0.0016	0.8248	0.9803
Brugia malayi	Dopamine receptor protein 2	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	sulfakinin receptor protein	0.0016	0.8248	0.7565
Echinococcus granulosus	neuropeptide FF receptor 2	0.0016	0.8248	0.9803
Echinococcus multilocularis	neuropeptide s receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	biogenic amine receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Echinococcus granulosus	dro:myosuppressin receptor	0.0016	0.8248	0.9803
Loa Loa (eye worm)	melatonin receptor type 1A	0.0016	0.8248	0.7565
Echinococcus granulosus	DNA directed RNA polymerase I subunit RPA1	0.0016	0.8358	1
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.8248	0.9803
Brugia malayi	Melatonin receptor type 1A	0.0016	0.8248	0.7565
Echinococcus multilocularis	allatostatin A receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	amine GPCR	0.0016	0.8248	0.7565
Echinococcus granulosus	serotonin receptor	0.0016	0.8248	0.9803
Treponema pallidum	DNA-directed RNA polymerase subunit beta'	0.0009	0.2808	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0016	0.8248	0.9803
Trypanosoma brucei	DNA-directed RNA polymerase III subunit C1	0.0009	0.2808	0.336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Onchocerca volvulus		0.0016	0.8248	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Leishmania major	DNA-directed rna polymerase I largest subunit, putative	0.0016	0.8358	1
Schistosoma mansoni	amine GPCR	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0016	0.8248	0.7565
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus granulosus	G protein coupled receptor 139	0.0016	0.8248	0.9803
Echinococcus multilocularis	G protein coupled receptor 139	0.0016	0.8248	0.9803
Wolbachia endosymbiont of Brugia malayi	DNA-directed RNA polymerase subunit beta/beta'	0.0009	0.2808	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.8248	0.9803
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0016	0.8248	0.9803
Brugia malayi	G protein-coupled receptor F59B2.13	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Mycobacterium leprae	DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT).	0.0009	0.2808	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	GnHR receptor homolog	0.0016	0.8248	0.7565
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Schistosoma mansoni	biogenic amine receptor	0.0016	0.8248	0.7565
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0016	0.8248	0.7565
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus granulosus	fmrfamide receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Onchocerca volvulus		0.0016	0.8248	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Brugia malayi	larval opioid receptor	0.0016	0.8248	0.7565
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	neuropeptide receptor A26	0.0016	0.8248	0.9803
Echinococcus multilocularis	g-protein coupled receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	growth hormone secretagogue receptor	0.0016	0.8248	0.7565
Brugia malayi	putative neuropeptide receptor NPR1	0.0016	0.8248	0.7565
Schistosoma mansoni	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus granulosus	7tm_1 domain containing protein	0.0016	0.8248	0.9803
Brugia malayi	G-protein coupled receptor	0.0016	0.8248	0.7565
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.8248	0.7565
Schistosoma mansoni	amine GPCR	0.0016	0.8248	0.7565
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Schistosoma mansoni	amine GPCR	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Onchocerca volvulus		0.0016	0.8248	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0016	0.8248	0.9803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0016	0.8248	0.7565
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0016	0.8248	0.7565
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	neuropeptide receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	DNA directed RNA polymerase I subunit RPA1	0.0016	0.8358	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0016	0.8248	0.7565
Schistosoma mansoni	opsin-like receptor	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Brugia malayi	Serotonin receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.8248	0.9803
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0016	0.8248	0.7565
Echinococcus granulosus	g protein coupled receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	neuropeptide receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.8248	0.9803
Entamoeba histolytica	DNA-directed RNA polymerase I largest subunit, putative	0.0018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0016	0.8248	0.7565
Echinococcus granulosus	g protein coupled receptor	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	dro:myosuppressin receptor	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	opsin-like receptor	0.0016	0.8248	0.7565
Echinococcus granulosus	hypothetical protein	0.0016	0.8248	0.9803
Schistosoma mansoni	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus granulosus	orexin receptor type 2	0.0016	0.8248	0.9803
Giardia lamblia	RNA polymerase AI large subunit	0.0018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.8248	0.9803
Trypanosoma brucei	DNA-directed RNA polymerase II subunit RPB1	0.0009	0.2808	0.336
Trypanosoma brucei	DNA-directed rna polymerase I largest subunit, putative	0.0016	0.8358	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0016	0.8248	0.7565
Echinococcus granulosus	7TM GPCR rhodopsin	0.0016	0.8248	0.9803
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Echinococcus granulosus	g protein coupled receptor	0.0016	0.8248	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Brugia malayi	neuropeptide F receptor	0.0016	0.8248	0.7565
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.8248	0.9803
Trypanosoma cruzi	DNA-directed rna polymerase I largest subunit, putative	0.0016	0.8358	1
Onchocerca volvulus		0.0016	0.8248	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.8248	0.7565
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0016	0.8248	0.9803
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Mycobacterium ulcerans	DNA-directed RNA polymerase subunit beta'	0.0009	0.2808	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.8248	0.9803
Plasmodium vivax	DNA-directed RNA polymerase I 190 kDa polypeptide, putative	0.0018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.8248	0.7565
Schistosoma mansoni	neuropeptide receptor	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0018	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0016	0.8248	0.7565
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.8248	0.9803
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.8248	0.9803
Onchocerca volvulus		0.0016	0.8248	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Toxoplasma gondii	DNA-directed RNA polymerase I RPA1	0.0018	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0016	0.8248	0.7565
Schistosoma mansoni	DNA-directed RNA polymerase I	0.0018	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	orexin receptor type 2	0.0016	0.8248	0.9803
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.8248	0.9803
Schistosoma mansoni	hypothetical protein	0.0016	0.8248	0.7565
Onchocerca volvulus		0.0016	0.8248	0.5
Schistosoma mansoni	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.8248	0.7565
Loa Loa (eye worm)	hypothetical protein	0.0016	0.8248	0.7565
Schistosoma mansoni	histamine h1 receptor	0.0016	0.8248	0.7565
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0016	0.8248	0.7565
Brugia malayi	hypothetical protein	0.0016	0.8248	0.7565
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.8248	0.9803
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.8248	0.9803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.8248	0.7565
Echinococcus granulosus	neuropeptide receptor	0.0016	0.8248	0.9803
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.8248	0.9803
Brugia malayi	G protein-coupled receptor	0.0016	0.8248	0.7565
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.8248	0.9803
Chlamydia trachomatis	DNA-directed RNA polymerase subunit beta'	0.0009	0.2808	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0016	0.8248	0.7565

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.09 uM	Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis	ChEMBL.	24847734
T1/2 (ADMET)	= 33 min	Half life in human liver microsomes at 1 uM preincubated for 5 mins followed by beta-NADPH addition	ChEMBL.	24847734

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3289421

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1917620