Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pisum sativum | Delta-aminolevulinic acid dehydratase, chloroplastic | Starlite/ChEMBL | References |
Wolbachia sp. subsp. Brugia malayi (strain TRS) | Delta-aminolevulinic acid dehydratase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | delta-aminolevulinic acid dehydratase, putative | 0.0517 | 1 | 0.5 |
Schistosoma mansoni | porphobilinogen synthase | 0.0517 | 1 | 0.5 |
Mycobacterium ulcerans | delta-aminolevulinic acid dehydratase | 0.0517 | 1 | 0.5 |
Schistosoma mansoni | porphobilinogen synthase | 0.0517 | 1 | 0.5 |
Plasmodium falciparum | porphobilinogen synthase | 0.0517 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | delta-aminolevulinic acid dehydratase | 0.0517 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) | 0.0517 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) | 0.0263 | 0 | 0.5 |
Toxoplasma gondii | parasite porphobilinogen synthase PBGS | 0.0517 | 1 | 0.5 |
Echinococcus multilocularis | delta aminolevulinic acid dehydratase | 0.0517 | 1 | 0.5 |
Echinococcus granulosus | delta aminolevulinic acid dehydratase | 0.0517 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 uM | Inhibition of C-terminal His-tagged Wolbachia PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 18.5 uM | Inhibition of Pisum sativum PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 94 uM | Inhibition of Pseudomonas aeruginosa PAO1 recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 197 uM | Inhibition of human PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 340 uM | Inhibition of Drosophila melanogaster recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
Smax (binding) | = 100 % | Stimulation of Escherichia coli recombinant PBGS using 5-ALA as substrate at 533 uM | ChEMBL. | 24568185 |
Smax (binding) | = 100 % | Stimulation of Vibrio cholerae recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate at 533 uM | ChEMBL. | 24568185 |
Smax (binding) | = 100 % | Stimulation of Yersinia enterocolitica recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate at 533 uM | ChEMBL. | 24568185 |
Smax (binding) | = 100 % | Stimulation of Pseudomonas aeruginosa PAO1 recombinant PBGS using 5-ALA as substrate at 533 uM | ChEMBL. | 24568185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.