Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | 5-aminolevulinate dehydratase (porphobilinogen synthase) | Starlite/ChEMBL | References |
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) | Delta-aminolevulinic acid dehydratase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | delta-aminolevulinic acid dehydratase, putative | 0.0517 | 1 | 0.5 |
Schistosoma mansoni | porphobilinogen synthase | 0.0517 | 1 | 0.5 |
Mycobacterium ulcerans | delta-aminolevulinic acid dehydratase | 0.0517 | 1 | 0.5 |
Plasmodium falciparum | porphobilinogen synthase | 0.0517 | 1 | 0.5 |
Schistosoma mansoni | porphobilinogen synthase | 0.0517 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | delta-aminolevulinic acid dehydratase | 0.0517 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) | 0.0517 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) | 0.0263 | 0 | 0.5 |
Toxoplasma gondii | parasite porphobilinogen synthase PBGS | 0.0517 | 1 | 0.5 |
Echinococcus multilocularis | delta aminolevulinic acid dehydratase | 0.0517 | 1 | 0.5 |
Echinococcus granulosus | delta aminolevulinic acid dehydratase | 0.0517 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 15 uM | Stimulation of Pseudomonas aeruginosa PAO1 recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
EC50 (binding) | = 19 uM | Stimulation of Escherichia coli recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
EC50 (binding) | = 23 uM | Stimulation of Yersinia enterocolitica recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate | ChEMBL. | 24568185 |
EC50 (binding) | = 38 uM | Stimulation of Vibrio cholerae recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | > 1 mM | Inhibition of Drosophila melanogaster recombinant PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | > 500 uM | Inhibition of Pisum sativum PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 500 uM | Inhibition of C-terminal His-tagged Wolbachia PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
IC50 (binding) | = 500 uM | Inhibition of human PBGS using 5-ALA as substrate | ChEMBL. | 24568185 |
Smax (binding) | = 116 % | Stimulation of Escherichia coli recombinant PBGS using 5-ALA as substrate relative to control | ChEMBL. | 24568185 |
Smax (binding) | = 117 % | Stimulation of Vibrio cholerae recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate relative to control | ChEMBL. | 24568185 |
Smax (binding) | = 123.2 % | Stimulation of Yersinia enterocolitica recombinant PBGS expressed in Escherichia coli using 5-ALA as substrate relative to control | ChEMBL. | 24568185 |
Smax (binding) | = 135.6 % | Stimulation of Pseudomonas aeruginosa PAO1 recombinant PBGS using 5-ALA as substrate relative to control | ChEMBL. | 24568185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.