Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable DNA topoisomerase II | 0.0712 | 1 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0517 | 0.5902 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0712 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 0.5096 | 0.4103 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0712 | 1 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0712 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 0.5096 | 0.4103 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0641 | 0.85 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0712 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0641 | 0.85 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0641 | 0.85 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0234 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0234 | 0 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0681 | 0.9342 | 0.5 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0234 | 0 | 0.5 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0712 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0517 | 0.5902 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0387 | 0.3184 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0712 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0641 | 0.85 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0234 | 0 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0712 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0641 | 0.85 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0712 | 1 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0712 | 1 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0517 | 0.5902 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0712 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.