Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.5 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0004 | 0.5 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0004 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 4 % | Partial antagonist activity at rat TRPV1 heterologously expressed in CHO cells assessed as inhibition of capsaicin-induced [45Ca2+] uptake by liquid scintillation counting | ChEMBL. | 24794110 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.