Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0218 | 0.5 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0218 | 0.5 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0218 | 0.5 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0218 | 0.5 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0218 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 53.6 % | Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells at 10 uM after 48 hrs by RP-HPLC analysis relative to control | ChEMBL. | 24844139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.