Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0178 | 0.4601 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0178 | 0.4601 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0178 | 0.4601 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0178 | 0.4601 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0178 | 0.4601 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0146 | 0.3138 | 0.682 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.4601 | 0.4601 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0178 | 0.4601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.3138 | 0.3138 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0178 | 0.4601 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0178 | 0.4601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.3138 | 0.3138 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0178 | 0.4601 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0178 | 0.4601 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0178 | 0.4601 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0146 | 0.3138 | 0.682 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0178 | 0.4601 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0178 | 0.4601 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0178 | 0.4601 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0146 | 0.3138 | 0.682 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0178 | 0.4601 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0178 | 0.4601 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0178 | 0.4601 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0178 | 0.4601 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0178 | 0.4601 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0178 | 0.4601 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0178 | 0.4601 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0146 | 0.3138 | 0.682 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0178 | 0.4601 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0178 | 0.4601 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | > 90 % | Inhibition of rat recombinant GluN1/2A expressed in Xenopus oocytes assessed as inhibition of glutamate/glycine-evoked channel current at 100 nM at holding potential of -80 mV by two-electrode voltage clamp technique | ChEMBL. | 24824658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.