Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0038 | 0.8241 | 0.8241 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0042 | 1 | 1 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0042 | 1 | 1 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0038 | 0.8241 | 0.8241 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0021 | 0.1235 | 0.1235 |
Mycobacterium ulcerans | adenylylate/guanylate cyclase | 0.0024 | 0.2386 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0042 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.