Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0169 | 1 | 1 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0169 | 1 | 1 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.015 | 0.8241 | 0.8241 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0169 | 1 | 1 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0169 | 1 | 1 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.015 | 0.8241 | 0.8241 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0169 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0169 | 1 | 1 |
Mycobacterium ulcerans | adenylylate/guanylate cyclase | 0.0107 | 0.4225 | 0.5 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0075 | 0.1235 | 0.1235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta MST (functional) | = 5.1 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 80 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 5.1 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 40 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 6.9 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 80 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 7.1 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice after subcutaneous administration dose of 20 mg/kg | ChEMBL. | 6227747 |
Delta MST (functional) | = 9.9 day | Antimalarial effect against Trophozoite-induced P. berghei in mice after subcutaneous administration dose of 160 mg/kg | ChEMBL. | 6227747 |
ID50 (functional) | = 0.000000027 M | Molar concentration required to reduce the number of L1210 cells by 50% after incubation for 2 days | ChEMBL. | 6227747 |
ID50 (functional) | = 0.000000035 M | Molar concentration required to reduce the number of L1210 cells by 50% after incubation for 2 days | ChEMBL. | 6227747 |
SD90 (functional) | = 1.9 mg kg-1 day-1 | Daily dose required for 90% parasitaemia in trophozoite induced P. berghei in 21 mice | ChEMBL. | 6227747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.