Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor (DP) | Starlite/ChEMBL | References |
Rattus norvegicus | Prostanoid IP receptor | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin I2 (prostacyclin) receptor (IP) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | prostaglandin D2 receptor (DP) | 359 aa | 312 aa | 23.1 % |
Schistosoma mansoni | biogenic amine receptor | Prostanoid IP receptor | 416 aa | 385 aa | 19.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine kinase | 0.0027 | 0.0499 | 0.0499 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0039 | 0.1672 | 0.1672 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0121 | 1 | 1 |
Leishmania major | extracellular receptor, putative | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0104 | 0.8328 | 0.8328 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0499 | 0.0499 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0121 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0121 | 1 | 1 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0121 | 1 | 1 |
Mycobacterium ulcerans | adenylylate/guanylate cyclase | 0.0094 | 0.7256 | 0.5 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0121 | 1 | 1 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0039 | 0.1672 | 0.1672 |
Schistosoma mansoni | tyrosine kinase | 0.0027 | 0.0499 | 0.0499 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0121 | 1 | 1 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0104 | 0.8328 | 0.8328 |
Schistosoma mansoni | tyrosine kinase | 0.0027 | 0.0499 | 0.0499 |
Onchocerca volvulus | 0.0039 | 0.1672 | 0.1672 | |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0027 | 0.0499 | 0.0499 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 33 nM | Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | ChEMBL. | 25666818 |
EC50 (binding) | = 42 nM | Agonist activity at human recombinant DP1 receptor expressed in melanophores assessed as induction of pigment redistribution incubated for 90 mins | ChEMBL. | 25666818 |
EC50 (binding) | = 266 nM | Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay | ChEMBL. | 25666818 |
IC50 (binding) | = 62 nM | Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation | ChEMBL. | 25666818 |
Intrinsic activity (binding) | = 94 % | Intrinsic activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay relative to 1 uM iloprost | ChEMBL. | 25666818 |
Intrinsic activity (binding) | = 103 % | Intrinsic activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay relative to 1 uM iloprost | ChEMBL. | 25666818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.