Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ROS proto-oncogene 1, receptor tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | anaplastic lymphoma receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TK protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Loa Loa (eye worm) | TK/ALK protein kinase | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Echinococcus multilocularis | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus granulosus | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.9884 | 0.9884 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0287 | 0.9848 | 0.9848 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.8407 | 0.8407 |
Onchocerca volvulus | 0.004 | 0.0225 | 1 | |
Loa Loa (eye worm) | TK protein kinase | 0.0291 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.9851 | 0.9851 |
Echinococcus granulosus | tyrosine protein kinase | 0.0291 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0291 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.108 uM | Inhibition of ROS1 (unknown origin) incubated for 20 mins followed by [33P]ATP addition measured after 120 mins by HotSpot assay | ChEMBL. | 25461320 |
IC50 (binding) | = 9.72 uM | Inhibition of ALK (unknown origin) incubated for 20 mins followed by [33P]ATP addition measured after 120 mins by HotSpot assay | ChEMBL. | 25461320 |
IC50 (binding) | = 73.4 uM | Inhibition of ROS1 in human HCC78 cells after 48 hrs by CellTitre-Glo assay | ChEMBL. | 25461320 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.