Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0473 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0412 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0412 | 0 | 0.5 |
Onchocerca volvulus | 0.0473 | 1 | 0.5 | |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0412 | 0 | 0.5 |
Onchocerca volvulus | 0.0473 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DIZ (functional) | Antimicrobial activity against Escherichia coli MTCC 1652 assessed as growth inhibition at 4 mg/ml after 24 hrs by agar well diffusion method | ChEMBL. | 25702850 | |
IZ (functional) | = 13 mm | Antimicrobial activity against Candida albicans MTCC 3017 assessed as growth inhibition at 4 mg/ml after 24 hrs by agar well diffusion method | ChEMBL. | 25702850 |
IZ (functional) | = 15 mm | Antimicrobial activity against Saccharomyces cerevisiae MTCC 170 assessed as growth inhibition at 4 mg/ml after 24 hrs by agar well diffusion method | ChEMBL. | 25702850 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.