Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 1 % | Antagonist activity against human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production at 1 uM by scintillation counting method | ChEMBL. | 25874336 |
Inhibition (binding) | = 3 % | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membranes at 1 uM incubated for 120 mins by scintillation counting method | ChEMBL. | 25874336 |
Inhibition (binding) | = 25 % | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cell membranes at 1 uM incubated for 60 mins by scintillation counting method | ChEMBL. | 25874336 |
Ki (binding) | = 110 nM | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cell membranes incubated for 120 mins by scintillation counting method | ChEMBL. | 25874336 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.