Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0153 | 0.1659 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0453 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0102 | 0.0234 | 0.0234 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0153 | 0.1659 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0102 | 0.0234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.01 | 0.0184 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0453 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0093 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100000 nM | Inhibition of human active MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 fluorogenic substrate assessed as fluorescent product release | ChEMBL. | 25921268 |
IC50 (binding) | = 100000 nM | Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 fluorogenic substrate assessed as fluorescent product release | ChEMBL. | 25921268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.